Altered mitochondrial respiration in peripheral blood mononuclear cells of post-acute sequelae of SARS-CoV-2 infection.

Autor: Dirajlal-Fargo S; Case Western Reserve University, Cleveland, OH, USA; Ann and Robert Lurie Children's Hospital, Chicago, IL, USA. Electronic address: Sahera.dirajlal-fargo@uhhospitals.org., Maison DP; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA. Electronic address: davidm22@hawaii.edu., Durieux JC; Case Western Reserve University, Cleveland, OH, USA. Electronic address: Jared.Durieux@UHhospitals.org., Andrukhiv A; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA. Electronic address: andru78@hawaii.eduNicholas., Funderburg N; Division of Medical Laboratory Science, School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA. Electronic address: Nicholas.Funderburg@osumc.edu., Ailstock K; Division of Medical Laboratory Science, School of Health and Rehabilitation Sciences, The Ohio State University, Columbus, OH, USA. Electronic address: Kate.Ailstock@osumc.edu., Gerschenson M; Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii at Manoa, Honolulu, HI, USA. Electronic address: gerschen@hawaii.edu., Mccomsey GA; Case Western Reserve University, Cleveland, OH, USA. Electronic address: grace.mccomsey@uhhospitals.org.
Jazyk: angličtina
Zdroj: Mitochondrion [Mitochondrion] 2024 Mar; Vol. 75, pp. 101849. Date of Electronic Publication: 2024 Feb 09.
DOI: 10.1016/j.mito.2024.101849
Abstrakt: Peripheral blood mononuclear cells (PBMC) mitochondrial respiration was measured ex vivo from participants without a history of COVID (n = 19), with a history of COVID and full recovery (n = 20), and with PASC (n = 20). Mean mitochondrial basal respiration, ATP-linked respiration, maximal respiration, spare respiration capacity, ATP-linked respiration, and non-mitochondrial respiration were highest in COVID + PASC+ (p ≤ 0.04). Every unit increase in non-mitochondrial respiration, ATP-linked respiration, basal respiration, spare respiration capacity, and maximal respiration increased the predicted odds of PASC between 1 % and 6 %. Mitochondrial dysfunction in PBMCs may be contributing to the etiology of PASC.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Author(s). Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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