Primary vulvar adenocarcinoma of intestinal type: Report of two cases showing molecular similarity with colorectal adenocarcinoma.

Autor: Mateoiu C; Department of Clinical Pathology, Sahlgrenska University Hospital, Gothenburg, Sweden. Electronic address: claudiamateoiu@gmail.com., Palicelli A; S.C. di Anat Patol Azienda USL-IRCCS, Ospedale S. Maria Nuova, di Reggio Emilia, Italy., Maloberti T; Solid Tumor Molecular Pathology Laboratory, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Italy., De Biase D; Solid Tumor Molecular Pathology Laboratory, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Italy; Department of Pharmacy and Biotechnology, University of Bologna, Italy., De Leo A; Solid Tumor Molecular Pathology Laboratory, IRCCS Azienda Ospedaliero-Universitaria di Bologna, University of Bologna, Italy; Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Italy., Lindh M; Department of Infectious Diseases, Institute of Biomedicine at the Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden., Bohlin KS; Department of Obstetrics and Gynecology, Sahlgrenska University Hospital, Gothenburg, Sweden., Stolnicu S; Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology 'George E Palade' of Targu Mures, Targu Mures, Romania.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2024 Mar; Vol. 255, pp. 155181. Date of Electronic Publication: 2024 Feb 01.
DOI: 10.1016/j.prp.2024.155181
Abstrakt: Primary vulvar adenocarcinoma is a particularly rare tumor with poorly understood histogenesis and unclear clinical characteristics and prognosis. Vulvar adenocarcinoma of intestinal type (VAIt) is a very uncommon subtype of primary vulvar adenocarcinoma and only 27 cases have been described in the literature in the past. Of these cases, two have been described as human papillomavirus (HPV)-associated VAIt. The current report presents two additional cases of primary VAIt showing variants in the KRAS, TP53, and DPYD genes and no evidence of HPV DNA by real-time polymerase chain reaction (RT-PCR). Next-generation sequencing (NGS) revealed TP53 pathogenic variants in both cases, but only one case had aberrant p53 protein immunohistochemical characteristics. KRAS and DPYD mutations were identified separately in the two cases. Due to their capacity to imitate the spread of more prevalent gastrointestinal carcinomas, these tumors may present diagnostic issues. Additional cases can contribute to a better understanding of the pathophysiology and prognosis of VAIt.
Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. I affirm that all the information provided in this Declaration of Interest statement is accurate and complete to the best of my knowledge.
(Copyright © 2024 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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