| Autor: |
Tejada S; Laboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, Spain.; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.; Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain., Sarubbo F; Laboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, Spain.; Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain., Jiménez-García M; Laboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, Spain.; Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain., Ramis MR; Laboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, Spain., Monserrat-Mesquida M; Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.; Research Group in Community Nutrition and Oxidative Stress (NUCOX), University of Balearic Islands, 07122 Palma de Mallorca, Spain., Quetglas-Llabrés MM; Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.; Research Group in Community Nutrition and Oxidative Stress (NUCOX), University of Balearic Islands, 07122 Palma de Mallorca, Spain., Capó X; Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.; Research Group in Community Nutrition and Oxidative Stress (NUCOX), University of Balearic Islands, 07122 Palma de Mallorca, Spain., Esteban S; Laboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, Spain.; Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain., Sureda A; CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain.; Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain.; Research Group in Community Nutrition and Oxidative Stress (NUCOX), University of Balearic Islands, 07122 Palma de Mallorca, Spain., Moranta D; Laboratory of Neurophysiology, University of the Balearic Islands, 07122 Palma de Mallorca, Spain.; Health Research Institute of Balearic Islands (IdISBa), 07120 Palma de Mallorca, Spain. |
| Abstrakt: |
Aging is a normal physiological process influenced by the combination of multiple mechanisms, primarily oxidative stress and neuroinflammation, which impact general physiology and brain function. Phenolic compounds have demonstrated the ability to slow down the aging process of the brain due to their antioxidant and anti-inflammatory effects. This study assessed the protective properties of catechin and polyphenon-60 in non-pathologically aged rats regarding visuo-spatial learning and the oxidative status of the frontal cortex. Old animals were treated with catechin or green tea extract (polyphenon-60) for 36 days, daily. Healthy old and young rats were used as controls. During the first training phase, treated rats executed the test better, locating the target in less time compared with the controls. Biomarkers of oxidative stress (catalase activities, superoxide dismutase, glutathione reductase, and glutathione S-transferase) were reduced in the brain of old animals, although their activities were partially improved after both antioxidant treatments. Furthermore, the rise in the production of reactive oxygen species and malondialdehyde levels-a marker of lipid peroxidation-in the frontal cortex of aged animals was significantly ameliorated after the interventions. In conclusion, old rats exhibited enhanced cognitive function and reduced stress levels following the administration of catechin and polyphenon-60. |
