| Autor: |
Patini R; Dipartimento di Testa-Collo ed Organi di Senso, Università Cattolica del Sacro Cuore, 00168 Rome, Italy., Favetti Giaquinto E; Dipartimento di Testa-Collo ed Organi di Senso, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; UOC Odontoiatria Generale e Ortodonzia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy., Gioco G; Dipartimento di Testa-Collo ed Organi di Senso, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; UOC Odontoiatria Generale e Ortodonzia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy., Castagnola R; Dipartimento di Testa-Collo ed Organi di Senso, Università Cattolica del Sacro Cuore, 00168 Rome, Italy., Perrotti V; Department of Medical, Oral and Biotechnological Sciences, 'G. d'Annunzio' University of Chieti-Pescara, 66100 Chieti, Italy., Rupe C; Dipartimento di Testa-Collo ed Organi di Senso, Università Cattolica del Sacro Cuore, 00168 Rome, Italy., Di Gennaro L; Hemorrhagic and Thrombotic Diseases Center, Department of Diagnostic Imaging, Radiotherapy, Oncology and Haematology, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy., Nocca G; Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; Fondazione Policlinico Universitario 'A. Gemelli', IRCCS, Largo Agostino Gemelli 8, 00168 Rome, Italy., Lajolo C; Dipartimento di Testa-Collo ed Organi di Senso, Università Cattolica del Sacro Cuore, 00168 Rome, Italy.; UOC Odontoiatria Generale e Ortodonzia, Dipartimento di Neuroscienze, Organi di Senso e Torace, Fondazione Policlinico Universitario A. Gemelli IRCCS, 00168 Rome, Italy. |
| Abstrakt: |
This systematic review and meta-analyses aimed to assess whether malnutrition may increase the incidence of oral cancer. Following the PRISMA statement, the research was conducted on PubMed, Scopus, and MEDLINE via OVID without any time restrictions. The risk of bias was assessed, and the quality of evidence for each performed meta-analysis was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) framework. Sixty-one articles met the inclusion criteria and seven studies underwent quantitative evaluation. For our meta-analysis on hypovitaminosis B, three studies with a total of 90,011 patients were included. An odds ratio of 2.22 was found. Our meta-analysis on the correlation between vitamin C and oral cancer included one study with a total of 866 patients and the derived odds ratio was 1.06. Our meta-analysis on the relationship between vitamin D deficiency and the incidence of oral cancer included three studies with a total of 12,087 patients and the odds ratio was -2.58. The GRADE system showed a moderate strength of evidence due to the presence of studies with a high risk of bias and high indirectness of the data given. The present findings suggest that an inadequate intake of vitamins, particularly vitamin D, poses a risk for the onset of oral cancer. |
