129 Xe MRI and Oscillometry of Irritant-Induced Asthma After Bronchial Thermoplasty.

Autor:	McIntosh MJ; Robarts Research Institute, Western University, London, ON, Canada; Department of Medical Biophysics, Western University, London, ON, Canada., Hofmann JJ; Robarts Research Institute, Western University, London, ON, Canada., Kooner HK; Robarts Research Institute, Western University, London, ON, Canada; Department of Medical Biophysics, Western University, London, ON, Canada., Eddy RL; Centre for Heart Lung Innovation, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada; Division of Respiratory Medicine, Department of Medicine, University of British Columbia, Vancouver, BC, Canada., Parraga G; Robarts Research Institute, Western University, London, ON, Canada; Department of Medical Biophysics, Western University, London, ON, Canada; Division of Respirology, Western University, London, ON, Canada. Electronic address: gparraga@uwo.ca., Mackenzie CA; Division of Respirology, Western University, London, ON, Canada; Division of Clinical Pharmacology and Toxicology, Department of Medicine, Western University, London, ON, Canada.
Jazyk:	angličtina
Zdroj:	Chest [Chest] 2024 Feb; Vol. 165 (2), pp. e27-e31.
DOI:	10.1016/j.chest.2023.09.010
Abstrakt:	Irritant-induced asthma (IIA) may develop after acute inhalational exposure in individuals without preexisting asthma. The effect of bronchial thermoplasty to treat intractable, worsening IIA has not yet been described. We evaluated a previously healthy 52-year-old man after inhalation of an unknown white powder. His pulmonary function and symptoms/quality of life worsened over 4 years, despite maximal guidelines-based asthma therapy. We acquired 129 Xe MRI and pulmonary function test measurements on three occasions including before and after bronchial thermoplasty treatment. Seven months after bronchial thermoplasty, improved MRI ventilation and oscillometry small airway resistance were observed. Spirometry and asthma control did not improve until 19 months after bronchial thermoplasty, 5.5 years postexposure. Together, oscillometry measurements of the small airways and 129 Xe MRI provided effort-independent, sensitive, and objective measurements of response to therapy. Improved MRI and oscillometry small airway resistance measurements temporally preceded improved airflow obstruction and may be considered for complex asthma cases. Competing Interests: Financial/Nonfinancial Disclosures The authors have reported to CHEST the following: R. L. E. discloses personal consulting fees from VIDA Diagnostics and Thorasys Thoracic Medical Systems, outside the submitted work. G. P. discloses investigator-initiated grants from GSK, Novartis, and AstraZeneca PLC, funding from the Ontario Ministry of Health and Long-term Care, and honoraria from AstraZeneca PLC, outside the submitted work. None declared (M. J. M., J. J. H., H. K. K., C. A. M.) (Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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