Pattern and value of Sperm DNA Fragmentation Index and its correlation with spermiogram in infertile South West Nigerian Men.

Autor: Ibitoye BO; Federal University of Technology, Akure, Nigeria. Electronic address: Ibicheun@gmail.com., Bashir FO; Omega Golden Fertility, Ajah Lagos, Nigeria., Ibitoye FO; Rufus Giwa Polytechnic, Ondo, Nigeria., Alabi O; Rufus Giwa Polytechnic, Ondo, Nigeria., Olaniyan OT; Rhema university, Aba, Nigeria., Faduola P; Androcare, Lagos, Nigeria., Bamisi OD; Ekiti State University, Ado Ekiti, Nigeria., Ajibare AJ; Lead City University, Ibadan, Nigeria., Omoseeye SD; Ekiti State University, Ado Ekiti, Nigeria.
Jazyk: angličtina
Zdroj: Morphologie : bulletin de l'Association des anatomistes [Morphologie] 2024 Jun; Vol. 108 (361), pp. 100763. Date of Electronic Publication: 2024 Feb 08.
DOI: 10.1016/j.morpho.2024.100763
Abstrakt: Semen analysis has been used for a long time to assess male fertility due to its limitations sperm DNA fragmentation index (DFI), which describes the sperm DNA's condition, is an appropriate criterion for assessing male fertility. This study evaluated the pattern and value of DFI of infertile men in the South West of Nigeria. This is a cross-sectional and descriptive study that recruited two hundred and eighty-seven (287) patients from two fertility centers in Lagos, Nigeria. The Sperm DFI was determined using the Sperm chromatin structure assay (SCSA) test. The descriptive and inferential statistics of the study were carried out using R packages (R version 4.2.0) with the help of R functions using compiled code. The result showed that the mean age sperm concentration, total motility morphology, and DFI were as follows 42.96±7.09years, 40.18±4.19×10 6 per ml, 49%±19%, 56±17%, and 15.78±8.52 respectively. There is a significant negative correlation between sperm concentration and DFI at a P-value of 0.0018 with a regression model of Coefficient of determination is 0.305. The DFI value of infertile men negatively correlates with sperm concentration, thus increase sperm production may improve sperm quality.
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Databáze: MEDLINE
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