Leaflet remodeling reduces tricuspid valve function in a computational model.

Autor: Mathur M; Department of Mechanical Engineering, University of Texas at Austin, 204 E Dean Keeton Street, Austin, 78712, TX, United States of America., Malinowski M; Division of Cardiothoracic Surgery, Spectrum Health, 221 Michigan Street NE Suite 300, Grand Rapids, 49503, MI, United States of America; Department of Cardiac Surgery, Medical University of Silesia, Katowice, Poland., Jazwiec T; Department of Cardiac, Vascular and Endovascular Surgery and Transplantology, Medical University of Silesia in Katowice, Silesian Centre for Heart Diseases, Zabrze, Poland., Timek TA; Division of Cardiothoracic Surgery, Spectrum Health, 221 Michigan Street NE Suite 300, Grand Rapids, 49503, MI, United States of America., Rausch MK; Department of Mechanical Engineering, University of Texas at Austin, 204 E Dean Keeton Street, Austin, 78712, TX, United States of America; Department of Aerospace Engineering and Engineering Mechanics, University of Texas at Austin, 2617 Wichita Street, Austin, 78712, TX, United States of America; Department of Biomedical Engineering, University of Texas at Austin, 107 W Dean Keeton Street, Austin, 78712, TX, United States of America; Oden Institute for Computational Engineering and Sciences, University of Texas at Austin, 201 E 24th Street, Austin, 78712, TX, United States of America. Electronic address: manuel.rausch@utexas.edu.
Jazyk: angličtina
Zdroj: Journal of the mechanical behavior of biomedical materials [J Mech Behav Biomed Mater] 2024 Apr; Vol. 152, pp. 106453. Date of Electronic Publication: 2024 Feb 02.
DOI: 10.1016/j.jmbbm.2024.106453
Abstrakt: Tricuspid valve leaflets have historically been considered "passive flaps". However, we have recently shown that tricuspid leaflets actively remodel in sheep with functional tricuspid regurgitation. We hypothesize that these remodeling-induced changes reduce leaflet coaptation and, therefore, contribute to valvular dysfunction. To test this, we simulated the impact of remodeling-induced changes on valve mechanics in a reverse-engineered computer model of the human tricuspid valve. To this end, we combined right-heart pressures and tricuspid annular dynamics recorded in an ex vivo beating heart, with subject-matched in vitro measurements of valve geometry and material properties, to build a subject-specific finite element model. Next, we modified the annular geometry and boundary conditions to mimic changes seen in patients with pulmonary hypertension. In this model, we then increased leaflet thickness and stiffness and reduced the stretch at which leaflets stiffen, which we call "transition-λ." Subsequently, we quantified mean leaflet stresses, leaflet systolic angles, and coaptation area as measures of valve function. We found that leaflet stresses, leaflet systolic angle, and coaptation area are sensitive to independent changes in stiffness, thickness, and transition-λ. When combining thickening, stiffening, and changes in transition-λ, we found that anterior and posterior leaflet stresses decreased by 26% and 28%, respectively. Furthermore, systolic angles increased by 43%, and coaptation area decreased by 66%; thereby impeding valve function. While only a computational study, we provide the first evidence that remodeling-induced leaflet thickening and stiffening may contribute to valvular dysfunction. Targeted suppression of such changes in diseased valves could restore normal valve mechanics and promote leaflet coaptation.
Competing Interests: Declaration of competing interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Manuel K. Rausch reports a relationship with Edwards Lifesciences Corporation that includes: speaking and lecture fees.
(Copyright © 2024 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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