Genetic Factors Associated With Adverse Pregnancy Outcomes in Chronic Pancreatitis.

Autor:	Wu D; Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.; Shanghai Institute of Pancreatic Diseases, Shanghai, China., Ru N; Department of Gastroenterology, The First Medical Center of Chinese People's Liberation Army General Hospital, Beijing, China.; Department of Gastroenterology, 987th Hospital of the Joint Logistics Support Force of the People's Liberation Army, Baoji, Shaanxi, China., Wang YC; Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.; Shanghai Institute of Pancreatic Diseases, Shanghai, China., Ma GX; Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.; Shanghai Institute of Pancreatic Diseases, Shanghai, China., Shi TY; Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China., Xiong SH; Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.; Shanghai Institute of Pancreatic Diseases, Shanghai, China., You AJ; Changhai Clinical Research Unit, Changhai Hospital, Naval Medical University, Shanghai, China., Wang L; Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China., Hu LH; Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China., Li ZS; Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.; Shanghai Institute of Pancreatic Diseases, Shanghai, China., Zou WB; Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.; Shanghai Institute of Pancreatic Diseases, Shanghai, China., Liao Z; Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai, China.; Shanghai Institute of Pancreatic Diseases, Shanghai, China.
Jazyk:	angličtina
Zdroj:	Clinical and translational gastroenterology [Clin Transl Gastroenterol] 2024 Apr 01; Vol. 15 (4), pp. e00691. Date of Electronic Publication: 2024 Apr 01.
DOI:	10.14309/ctg.0000000000000691
Abstrakt:	Introduction: The effects of genetic factors on pregnancy outcomes in chronic pancreatitis (CP) patients remain unclear. We evaluated the impacts of clinical features and mutations in main CP-susceptibility genes ( SPINK1 , PRSS1 , CTRC , and CFTR ) on pregnancy outcomes in Chinese CP patients. Methods: This was a prospective cohort study with 14-year follow-up. The sample comprised female CP patients with documented pregnancy and known genetic backgrounds. Adverse pregnancy outcomes were compared between patients with and without gene mutations. Univariate and multivariate analyses were performed to determine the impact factors for adverse pregnancy outcomes. Results: Totally, 160 female CP patients with a pregnancy history were enrolled; 59.4% of patients carried pathogenic mutations in CP-susceptibility genes. Adverse pregnancy outcomes occurred in 38 patients (23.8%); the prevalence of adverse outcomes was significantly higher in those harboring gene mutations than those without (30.5% vs 13.8%, P = 0.015). Notably, the rates of preterm delivery (12.6% vs 3.1%, P = 0.036) and abortion (17.9% vs 4.6%, P = 0.013) were remarkably higher in patients with gene mutations (especially SPINK1 mutations) than those without. In multivariate analyses, both CP-susceptibility gene mutations (odds ratio, 2.52; P = 0.033) and SPINK1 mutations (odds ratio, 2.60; P = 0.037) significantly increased the risk of adverse pregnancy outcomes. Acute pain attack during pregnancy was another risk factor for adverse pregnancy outcomes. Discussion: Pathogenic mutations in CP-susceptibility genes, especially SPINK1 , were independently related to adverse pregnancy outcomes in CP patients. Significant attention should be paid to pregnant females harboring CP-susceptibility gene mutations (ClinicalTrials.gov: NCT06055595). (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of The American College of Gastroenterology.)
Databáze:	MEDLINE
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