Overcoming the Boundaries of Heart Warm Ischemia in Donation After Circulatory Death: The Padua Case.

Autor:	Gerosa G; From the Cardiac Surgery Unit, Cardio-Thoraco-Vascular and Public Health Department, Padova University Hospital, Padova, Italy., Zanatta P; Department of Critical Care, Anesthesiology and Intensive Care Unit, Ca' Foncello Hospital, Treviso, Italy., Angelini A; Cardiovascular Pathology, Cardio-Thoraco-Vascular and Public Health Department, Padova University Hospital, Padova, Italy., Fedrigo M; Cardiovascular Pathology, Cardio-Thoraco-Vascular and Public Health Department, Padova University Hospital, Padova, Italy., Bianco R; From the Cardiac Surgery Unit, Cardio-Thoraco-Vascular and Public Health Department, Padova University Hospital, Padova, Italy., Pittarello D; Cardiac Surgery Anesthesiology and Intensive Care Unit, Cardio-Thoraco-Vascular and Public Health Department, Padova University Hospital, Padova, Italy., Lena T; From the Cardiac Surgery Unit, Cardio-Thoraco-Vascular and Public Health Department, Padova University Hospital, Padova, Italy., Pepe A; Institute of Radiology, Department of Medicine, University of Padua, Padua, Italy., Toscano G; From the Cardiac Surgery Unit, Cardio-Thoraco-Vascular and Public Health Department, Padova University Hospital, Padova, Italy., Zanella F; From the Cardiac Surgery Unit, Cardio-Thoraco-Vascular and Public Health Department, Padova University Hospital, Padova, Italy., Feltrin G; Regional Health Department, Regional Transplant Center, Veneto Region, Italy., Pradegan N; From the Cardiac Surgery Unit, Cardio-Thoraco-Vascular and Public Health Department, Padova University Hospital, Padova, Italy., Tarzia V; From the Cardiac Surgery Unit, Cardio-Thoraco-Vascular and Public Health Department, Padova University Hospital, Padova, Italy.
Jazyk:	angličtina
Zdroj:	ASAIO journal (American Society for Artificial Internal Organs : 1992) [ASAIO J] 2024 Aug 01; Vol. 70 (8), pp. e113-e117. Date of Electronic Publication: 2024 Feb 09.
DOI:	10.1097/MAT.0000000000002141
Abstrakt:	A 45 year old male obese patient with a previous history of repaired congenital heart disease developed worsening heart failure making heart transplantation listing mandatory. Unfortunately, due to his anthropometric measures, the search for a suitable brain-dead donor was unsuccessful. For this reason, he accepted to be enrolled in the controlled donation after circulatory death (cDCD) program. According to the Italian Law regulating death declaration after cardiac arrest (no-touch period of 20 minutes-one of the longest in the world), we faced a 34 minute cardiac asystole, after which the heart was recovered through a thoraco-abdominal normothermic regional perfusion excluding the epiaortic vessels. The heart was then preserved by means of cold static storage. Heart transplantation was performed successfully without any signs of primary graft failure. Postoperative endomyocardial biopsies were negative for acute cellular and antibody-mediated rejection. Furthermore, echocardiographic and cardiac magnetic resonance evaluation of the heart did not show any functional abnormalities. The patient was discharged on post-operative day (POD) #39 in good clinical conditions. Competing Interests: Disclosure: The authors have no conflicts of interest to report. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the ASAIO.)
Databáze:	MEDLINE
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