Efficacy of the iron-chelating agent, deferiprone, in patients with Parkinson's disease: A systematic review and meta-analysis.

Autor: Negida A; Parkinson's and Movement Disorder Center, Virginia Commonwealth University, Richmond, Virginia, USA.; Medical Research Group of Egypt, Negida Academy, Arlington, Massachusetts, USA., Hassan NM; Medical Research Group of Egypt, Negida Academy, Arlington, Massachusetts, USA., Aboeldahab H; Medical Research Group of Egypt, Negida Academy, Arlington, Massachusetts, USA.; Biomedical Informatics and Medical Statistics Department, Medical Research Institute, Alexandria University, Alexandria, Egypt.; Clinical Research Department, El-Gomhoria General Hospital, Ministry of health and population, Alexandria, Egypt., Zain YE; Medical Research Group of Egypt, Negida Academy, Arlington, Massachusetts, USA.; Faculty of Medicine, Tanta University, Tanta, Egypt., Negida Y; Medical Research Group of Egypt, Negida Academy, Arlington, Massachusetts, USA.; Faculty of Medicine, Zagazig University, Zagazig, Egypt., Cadri S; Medical Research Group of Romania, Negida Academy, Arlington, Massachusetts, USA.; Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania., Cadri N; Medical Research Group of Romania, Negida Academy, Arlington, Massachusetts, USA.; Grigore T. Popa University of Medicine and Pharmacy, Iasi, Romania., Cloud LJ; Parkinson's and Movement Disorder Center, Virginia Commonwealth University, Richmond, Virginia, USA., Barrett MJ; Parkinson's and Movement Disorder Center, Virginia Commonwealth University, Richmond, Virginia, USA., Berman B; Parkinson's and Movement Disorder Center, Virginia Commonwealth University, Richmond, Virginia, USA.
Jazyk: angličtina
Zdroj: CNS neuroscience & therapeutics [CNS Neurosci Ther] 2024 Feb; Vol. 30 (2), pp. e14607.
DOI: 10.1111/cns.14607
Abstrakt: Introduction: Several studies have reported iron accumulation in the basal ganglia to be associated with the development of Parkinson's Disease (PD). Recently, a few trials have examined the efficacy of using the iron-chelating agent Deferiprone (DFP) for patients with PD. We conducted this meta-analysis to summarize and synthesize evidence from published randomized controlled trials about the efficacy of DFP for PD patients.
Methods: A comprehensive literature search of four electronic databases was performed, spanning until February 2023. Relevant RCTs were selected, and their data were extracted and analyzed using the RevMan software. The primary outcome was the change in the Unified Parkinson's Disease Rating Scale (UPDRS-III).
Results: Three RCTs with 431 patients were included in this analysis. DFP did not significantly improve UPDRS-III score compared to placebo (Standardized mean difference -0.06, 95% CI [-0.69, 0.58], low certainty evidence). However, it significantly reduced iron accumulation in the substantia nigra, putamen, and caudate as measured by T2*-weighted MRI (with high certainty evidence).
Conclusion: Current evidence does not support the use of DFP in PD patients. Future disease-modification trials with better population selection, adjustment for concomitant medications, and long-term follow up are recommended.
(© 2024 The Authors. CNS Neuroscience & Therapeutics published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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