Tau accumulation and atrophy predict amyloid independent cognitive decline in aging.

Autor: Fonseca CS; Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA., Baker SL; Lawrence Berkeley National Laboratory, Berkeley, California, USA., Dobyns L; Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA., Janabi M; Lawrence Berkeley National Laboratory, Berkeley, California, USA., Jagust WJ; Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA.; Lawrence Berkeley National Laboratory, Berkeley, California, USA., Harrison TM; Helen Wills Neuroscience Institute, University of California, Berkeley, California, USA.
Jazyk: angličtina
Zdroj: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Apr; Vol. 20 (4), pp. 2526-2537. Date of Electronic Publication: 2024 Feb 09.
DOI: 10.1002/alz.13654
Abstrakt: Introduction: Amyloid beta (Aβ) and tau pathology are cross-sectionally associated with atrophy and cognitive decline in aging and Alzheimer's disease (AD).
Methods: We investigated relationships between concurrent longitudinal measures of Aβ (Pittsburgh compound B [PiB] positron emission tomography [PET]), tau (flortaucipir [FTP] PET), atrophy (structural magnetic resonance imaging), episodic memory (EM), and non-memory (NM) in 78 cognitively healthy older adults (OA).
Results: Entorhinal FTP change was correlated with EM decline regardless of Aβ, but meta-temporal FTP and global PiB change were only associated with EM and NM decline in Aβ+ OA. Voxel-wise analyses revealed significant associations between temporal lobe FTP change and EM decline in all groups. PiB and FTP change were not associated with structural change, suggesting a functional or microstructural mechanism linking these measures to cognitive decline.
Discussion: Our results show that longitudinal Aβ is linked to cognitive decline only in the presence of elevated Aβ, but longitudinal temporal lobe tau is associated with memory decline regardless of Aβ status.
Highlights: Entorhinal tau change was associated with memory decline in older adults (OA), regardless of amyloid beta (Aβ). Greater meta-region of interest (ROI) tau change correlated with memory decline in Aβ+ OA. Voxel-wise temporal tau change correlated with memory decline, regardless of Aβ. Meta-ROI tau and global amyloid change correlated with non-memory change in Aβ+ OA. Tau and amyloid accumulation were not associated with structural change in OA.
(© 2024 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
Databáze: MEDLINE
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