Musical experience influences socio-emotional functioning in behavioural variant frontotemporal dementia.

Autor:	Van't Hooft JJ; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.; Alzheimer Centre Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.; Amsterdam Neuroscience-Neurodegeneration, Amsterdam, Netherlands., Benhamou E; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Albero Herreros C; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Jiang J; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Levett B; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Core LB; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Requena-Komuro MC; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Hardy CJD; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom., Tijms BM; Alzheimer Centre Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.; Amsterdam Neuroscience-Neurodegeneration, Amsterdam, Netherlands., Pijnenburg YAL; Alzheimer Centre Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, Netherlands.; Amsterdam Neuroscience-Neurodegeneration, Amsterdam, Netherlands., Warren JD; Dementia Research Centre, UCL Queen Square Institute of Neurology, University College London, London, United Kingdom.
Jazyk:	angličtina
Zdroj:	Frontiers in neurology [Front Neurol] 2024 Jan 24; Vol. 15, pp. 1341661. Date of Electronic Publication: 2024 Jan 24 (Print Publication: 2024).
DOI:	10.3389/fneur.2024.1341661
Abstrakt:	Objectives: On phenotypic and neuroanatomical grounds, music exposure might potentially affect the clinical expression of behavioural variant frontotemporal dementia (bvFTD). However, this has not been clarified. Methods: 14 consecutive patients with bvFTD fulfilling consensus diagnostic criteria were recruited via a specialist cognitive clinic. Earlier life musical experience, current musical listening habits and general socio-emotional behaviours were scored using a bespoke semi-quantitative musical survey and standardised functional scales, completed with the assistance of patients' primary caregivers. Associations of musical scores with behavioural scales were assessed using a linear regression model adjusted for age, sex, educational attainment and level of executive and general cognitive impairment. Results: Greater earlier life musical experience was associated with significantly lower Cambridge Behavioural Inventory (Revised) scores (β ± SE = -17.2 ± 5.2; p  = 0.01) and higher Modified Interpersonal Reactivity Index (MIRI) perspective-taking scores (β ± SE = 2.8 ± 1.1; p  = 0.03), after adjusting for general cognitive ability. Number of hours each week currently spent listening to music was associated with higher MIRI empathic concern (β ± SE = 0.7 ± 0.21; p  = 0.015) and MIRI total scores (β ± SE = 1.1 ± 0.34; p  = 0.014). Discussion: Musical experience in earlier life and potentially ongoing regular music listening may ameliorate socio-emotional functioning in bvFTD. Future work in larger cohorts is required to substantiate the robustness of this association, establish its mechanism and evaluate its clinical potential. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (Copyright © 2024 van’t Hooft, Benhamou, Albero Herreros, Jiang, Levett, Core, Requena-Komuro, Hardy, Tijms, Pijnenburg and Warren.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu