| Autor: |
Gallardo-Pérez MM; Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, México.; Universidad Popular Autónoma del Estado de Puebla, Puebla, México., Gutiérrez-Aguirre CH; Hospital Universitario 'Dr. José Eleuterio González' de la Universidad Autónoma de Nuevo León, Monterrey, México., Olivares-Gazca JC; Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, México.; Universidad Popular Autónoma del Estado de Puebla, Puebla, México., Ruiz-Argüelles GJ; Centro de Hematología y Medicina Interna, Clínica Ruiz, Puebla, México.; Universidad Popular Autónoma del Estado de Puebla, Puebla, México. |
| Jazyk: |
angličtina |
| Zdroj: |
Hematology (Amsterdam, Netherlands) [Hematology] 2024 Dec; Vol. 29 (1), pp. 2313357. Date of Electronic Publication: 2024 Feb 08. |
| DOI: |
10.1080/16078454.2024.2313357 |
| Abstrakt: |
Haploidentical hematopoietic can be conducted on an outpatient basis but the two main reasons to accept into the hospital a patient in this setting are complications of the hematological toxicity and/or the cytokine-release syndrome. With the aim of reducing the post-transplant cyclophosphamide-dependent toxicity without compromising its effectivity, attempts to reduce the dose of post-transplant cyclophosphamide have been made: Decreases from the conventional total dose of post-transplant cyclophosphamide (100 mg/Kg) have been explored worldwide, showing that decreasing the total dose to even 50 mg/Kg significantly decreases the toxicity of the procedure without compromising its efficacy, safety and results. We present here the salient data of the attempts to diminish the doses of post-transplant cyclophosphamide which have been done and published worldwide, information that suggests that the conventional doses of post-transplant cyclophosphamide can be significantly reduced thus decreasing the toxicity, without compromising the effectiveness of the procedure, mainly the development of graft versus host disease. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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