The impact of kidney stone disease on quality of life in high-risk stone formers.

Autor: Assad A; Division of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada., Raizenne BL; Division of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada., El Yamani MEM; Division of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada., Saud A; Division of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada., Bechis SK; Department of Urology, University of California San Diego, San Diego, CA, USA., Sur RL; Department of Urology, University of California San Diego, San Diego, CA, USA., Nakada SY; Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Streeper NM; Department of Urology, Pennsylvania State University College of Medicine, Hershey, PA, USA., Sivalingam S; Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH, USA., Pais VM Jr; Urology Section, Dartmouth Hitchcock Medical Center, Lebanon, NH, USA., Chew BH; Department of Urologic Sciences, University of British Columbia, Vancouver, British Columbia, Canada., Bird VG; Department of Urology, University of Florida College of Medicine, Gainesville, FL, USA., Andonian S; Division of Urology, McGill University Health Center, Montreal, Quebec, Canada., Penniston KL; Department of Urology, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Bhojani N; Division of Urology, Centre Hospitalier de l'Université de Montréal, Montréal, Quebec, Canada.
Jazyk: angličtina
Zdroj: BJU international [BJU Int] 2024 May; Vol. 133 (5), pp. 570-578. Date of Electronic Publication: 2024 Feb 08.
DOI: 10.1111/bju.16294
Abstrakt: Objective: To assess the impact of kidney stone disease (KSD) and its treatment on the health-related quality of life (HRQOL) of high-risk stone formers with hyperparathyroidism, renal tubular acidosis, malabsorptive disease, and medullary sponge kidney.
Patients and Methods: The Wisconsin Stone Quality of Life questionnaire was used to evaluate HRQOL in 3301 patients with a history of KSD from 16 institutions in North America between 2014 and 2020. Baseline characteristics and medical history were collected from patients, while active KSD was confirmed through radiological imaging. The high-risk group was compared to the remaining patients (control group) using the Wilcoxon rank-sum test.
Results: Of 1499 patients with active KSD included in the study, the high-risk group included 120 patients. The high-risk group had significantly lower HRQOL scores compared to the control group (P < 0.01). In the multivariable analyses, medullary sponge kidney disease and renal tubular acidosis were independent predictors of poorer HRQOL, while alkali therapy was an independent predictor of better HRQOL (all P < 0.01).
Conclusions: Among patients with active KSD, high-risk stone formers had impaired HRQOL with medullary sponge kidney disease and renal tubular acidosis being independent predictors of poorer HRQOL. Clinicians should seek to identify these patients earlier as they would benefit from prompt treatment and prevention.
(© 2024 The Authors. BJU International published by John Wiley & Sons Ltd on behalf of BJU International.)
Databáze: MEDLINE
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