Efficacy and safety of using auditory-motor entrainment to improve walking after stroke: a multi-site randomized controlled trial of InTandem TM .

Autor: Awad LN; Dept. of Physical Therapy, Boston University, Boston, MA, USA. louawad@bu.edu.; Dept. of PM&R, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA, USA. louawad@bu.edu., Jayaraman A; Dept. of PM&R, Northwestern University, Shirley Ryan AbilityLab, Chicago, IL, USA., Nolan KJ; Center for Mobility and Rehabilitation Engineering, Kessler Foundation, West Orange, NJ, USA.; Dept. of PM&R, Rutgers New Jersey Medical School, Kessler Rehabilitation, Newark, NJ, USA., Lewek MD; Dept. of Health Sciences, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.; Division of Physical Therapy, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA., Bonato P; Dept. of PM&R, Harvard Medical School, Spaulding Rehabilitation Hospital, Boston, MA, USA., Newman M; Dept. of PM&R, Carolinas Rehabilitation, Charlotte, NC, USA., Putrino D; Abilities Research Center, Icahn School of Medicine at Mount Sinai, New York, NY, USA., Raghavan P; Depts. of PM&R & Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA., Pohlig RT; College of Health Sciences, University of Delaware, Newark, DE, USA., Harris BA; MedRhythms, Inc., Portland, ME, USA., Parker DA; MedRhythms, Inc., Portland, ME, USA., Taylor SR; MedRhythms, Inc., Portland, ME, USA.
Jazyk: angličtina
Zdroj: Nature communications [Nat Commun] 2024 Feb 08; Vol. 15 (1), pp. 1081. Date of Electronic Publication: 2024 Feb 08.
DOI: 10.1038/s41467-024-44791-5
Abstrakt: Walking slowly after stroke reduces health and quality of life. This multi-site, prospective, interventional, 2-arm randomized controlled trial (NCT04121754) evaluated the safety and efficacy of an autonomous neurorehabilitation system (InTandem TM ) designed to use auditory-motor entrainment to improve post-stroke walking. 87 individuals were randomized to 5-week walking interventions with InTandem or Active Control (i.e., walking without InTandem). The primary endpoints were change in walking speed, measured by the 10-meter walk test pre-vs-post each 5-week intervention, and safety, measured as the frequency of adverse events (AEs). Clinical responder rates were also compared. The trial met its primary endpoints. InTandem was associated with a 2x larger increase in speed (Δ: 0.14 ± 0.03 m/s versus Δ: 0.06 ± 0.02 m/s, F(1,49) = 6.58, p = 0.013), 3x more responders (40% versus 13%, χ 2 (1) ≥ 6.47, p = 0.01), and similar safety (both groups experienced the same number of AEs). The auditory-motor intervention autonomously delivered by InTandem is safe and effective in improving walking in the chronic phase of stroke.
(© 2024. The Author(s).)
Databáze: MEDLINE
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