Expanding the Imaging Spectrum of Polymorphous Low-Grade Neuroepithelial Tumor of the Young in Children.

Autor:	Cerron-Vela C; From the Department of Radiology (C.C.-V., F.G.G., L.O.T.-G., A.V.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania cerronvelc@chop.edu., Gonçalves FG; From the Department of Radiology (C.C.-V., F.G.G., L.O.T.-G., A.V.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Viaene AN; Department of Pathology and Laboratory Medicine (A.N.V.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Tierradentro-García LO; From the Department of Radiology (C.C.-V., F.G.G., L.O.T.-G., A.V.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania., Vossough A; From the Department of Radiology (C.C.-V., F.G.G., L.O.T.-G., A.V.), Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Jazyk:	angličtina
Zdroj:	AJNR. American journal of neuroradiology [AJNR Am J Neuroradiol] 2024 Apr 08; Vol. 45 (4), pp. 483-487. Date of Electronic Publication: 2024 Apr 08.
DOI:	10.3174/ajnr.A8145
Abstrakt:	Polymorphous low-grade neuroepithelial tumors of the young (PLNTY) are rare brain tumors first described in 2017 and recently included in the 2021 5th World Health Organization Classification of Tumors of the Central Nervous System. They typically affect children and young adults. Few pediatric cases have been reported in the literature. The most common imaging features described, include location within the temporal lobe, involvement of the cortical/subcortical region, coarse calcifications, and well-defined margins with solid and cystic morphology, with slight-or-no enhancement. However, there is limited information on imaging features in children. We present the imaging spectrum of neuroimaging features in a series of pediatric patients with a histologically and molecularly proved PLNTY diagnosis. Coarse calcifications are uncommon in children compared with the adult literature, and they may develop with time. The transmantle-like sign can be observed, and adjacent cortical dysplasia may be seen. Seizure recurrence may occur despite gross total resection of the tumor. (© 2024 by American Journal of Neuroradiology.)
Databáze:	MEDLINE
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