Neutrophil-to-lymphocyte ratio and all-cause mortality with and without myeloproliferative neoplasms-a Danish longitudinal study.

Autor: Larsen MK; Department of Hematology, Zealand University Hospital, Roskilde, Denmark. Mortenkrankerlarsen1@hotmail.com.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. Mortenkrankerlarsen1@hotmail.com., Skov V; Department of Hematology, Zealand University Hospital, Roskilde, Denmark., Kjær L; Department of Hematology, Zealand University Hospital, Roskilde, Denmark., Eickhardt-Dalbøge CS; Department of Hematology, Zealand University Hospital, Roskilde, Denmark., Knudsen TA; Department of Hematology, Zealand University Hospital, Roskilde, Denmark., Kristiansen MH; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Neurology, Zealand University Hospital, Roskilde, Denmark., Sørensen AL; Department of Hematology, Zealand University Hospital, Roskilde, Denmark., Wienecke T; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Neurology, Zealand University Hospital, Roskilde, Denmark., Andersen M; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Ottesen JT; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Gudmand-Høyer J; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Snyder JA; Department of Science and Environment, Roskilde University, Roskilde, Denmark., Andersen MP; Department of Cardiology, Copenhagen University Hospital, Nordsjællands Hospital, Hillerød, Denmark., Torp-Pedersen C; Department of Cardiology, Copenhagen University Hospital, Nordsjællands Hospital, Hillerød, Denmark., Poulsen HE; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Cardiology, Copenhagen University Hospital, Nordsjællands Hospital, Hillerød, Denmark.; Department of Endocrinology, Copenhagen University Hospital, Bispebjerg Frederiksberg Hospital, Copenhagen, Denmark., Stiehl T; Department of Science and Environment, Roskilde University, Roskilde, Denmark.; Institute for Computational Biomedicine - Disease Modelling, Faculty of Medicine, RWTH Aachen University, Aachen, Germany., Hasselbalch HC; Department of Hematology, Zealand University Hospital, Roskilde, Denmark.; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Ellervik C; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.; Department of Clinical Biochemistry, Zealand University Hospital, Koege, Denmark.; Department of Laboratory Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA.
Jazyk: angličtina
Zdroj: Blood cancer journal [Blood Cancer J] 2024 Feb 09; Vol. 14 (1), pp. 28. Date of Electronic Publication: 2024 Feb 09.
DOI: 10.1038/s41408-024-00994-z
Abstrakt: The neutrophil-to-lymphocyte ratio(NLR) is increased in chronic inflammation and myeloproliferative neoplasms (MPN). We hypothesize that NLR is associated with all-cause mortality and mortality by comorbidity burden in the general population and individuals with MPN. We included 835,430 individuals from The Danish General Suburban Population Study, general practitioners, and outpatient clinics. We investigated NLR on mortality stratified by prevalent and incident MPN, essential thrombocythemia (ET), polycythemia vera (PV), myelofibrosis (MF), comorbidity burden (CCI-score), and the Triple-A risk score using hazard ratio (HR) and 95% confidence interval (95%CI). NLR 1-1.9 was the reference level. During a median follow-up of 11.2 years, 197,802 deaths were recorded. All-cause mortality increased for a stepwise increasing NLR with a HR (95%CI) for NLR ≥ 6 of 2.06(2.03-2.09) for the whole population and 2.93(2.44-3.50) in prevalent MPN. ET, PV, and MF had a HR (95%CI) for NLR ≥ 2 of 2.14(1.71-2.69), 2.19(1.89-2.54), and 2.31(1.91-2.80). Results were similar for incident MPN. Mortality was higher for stepwise increasing NLR and CCI-score(p interaction  < 2×10 -16 ), with a HR for NLR ≥ 6 of 2.23(2.17-2.29), 4.10(4.01-4.20), and 7.69(7.50-7.89), for CCI-score 0, 1-2, or ≥3. The Triple-A risk score demonstrated alignment with NLR. Increasing NLR and comorbidity burden were associated with lower survival in individuals without MPN but were even worse in prevalent and incident MPN, ET, PV, and MF.
(© 2024. The Author(s).)
Databáze: MEDLINE
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