Enhancing cognitive control with transcranial magnetic stimulation in subject-specific frontoparietal networks.

Autor: Dengler J; School of Biomedical Engineering Science and Health Systems, Drexel University, Philadelphia, PA, USA., Deck BL; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA., Stoll H; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA., Fernandez-Nunez G; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA., Kelkar AS; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA., Rich RR; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA., Erickson BA; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA., Erani F; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA., Faseyitan O; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA., Hamilton RH; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA., Medaglia JD; Department of Psychological & Brain Sciences, Drexel University, Philadelphia, PA, USA; Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA. Electronic address: jdm582@drexel.edu.
Jazyk: angličtina
Zdroj: Cortex; a journal devoted to the study of the nervous system and behavior [Cortex] 2024 Mar; Vol. 172, pp. 141-158. Date of Electronic Publication: 2024 Jan 19.
DOI: 10.1016/j.cortex.2023.11.020
Abstrakt: Background: Cognitive control processes, including those involving frontoparietal networks, are highly variable between individuals, posing challenges to basic and clinical sciences. While distinct frontoparietal networks have been associated with specific cognitive control functions such as switching, inhibition, and working memory updating functions, there have been few basic tests of the role of these networks at the individual level.
Methods: To examine the role of cognitive control at the individual level, we conducted a within-subject excitatory transcranial magnetic stimulation (TMS) study in 19 healthy individuals that targeted intrinsic ("resting") frontoparietal networks. Person-specific intrinsic networks were identified with resting state functional magnetic resonance imaging scans to determine TMS targets. The participants performed three cognitive control tasks: an adapted Navon figure-ground task (requiring set switching), n-back (working memory), and Stroop color-word (inhibition).
Objective: Hypothesis: We predicted that stimulating a network associated with externally oriented control [the "FPCN-B" (fronto-parietal control network)] would improve performance on the set switching and working memory task relative to a network associated with attention (the Dorsal Attention Network, DAN) and cranial vertex in a full within-subjects crossover design.
Results: We found that set switching performance was enhanced by FPCN-B stimulation along with some evidence of enhancement in the higher-demand n-back conditions.
Conclusion: Higher task demands or proactive control might be a distinguishing role of the FPCN-B, and personalized intrinsic network targeting is feasible in TMS designs.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 The Authors. Published by Elsevier Ltd.. All rights reserved.)
Databáze: MEDLINE
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