Relationships between plasma neurofilament light chain protein, cognition, and brain aging in people with HIV.

Autor:	Cooley SA; Department of Neurology, Washington University in St. Louis, St. Louis, MO., Petersen KJ; Department of Neurology, Washington University in St. Louis, St. Louis, MO., Tice C; Department of Neural Sciences., Langford D; Department of Neural Sciences., Burdo TH; Department of Microbiology, Immunology, and Inflammation, Center for Neurovirology and Gene Editing, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, USA., Roman J; Department of Neurology, Washington University in St. Louis, St. Louis, MO., Ances BM; Department of Neurology, Washington University in St. Louis, St. Louis, MO.
Jazyk:	angličtina
Zdroj:	AIDS (London, England) [AIDS] 2024 Jun 01; Vol. 38 (7), pp. 955-962. Date of Electronic Publication: 2024 Feb 06.
DOI:	10.1097/QAD.0000000000003861
Abstrakt:	Objective: Neurofilament light chain protein (NfL) is a marker of neuronal injury and neurodegeneration. Typically assessed in cerebrospinal fluid, recent advances have allowed this biomarker to be more easily measured in plasma. This study assesses plasma NfL in people with HIV (PWH) compared with people without HIV (PWoH), and its relationship with cognitive impairment, cardiovascular risk, and a neuroimaging metric of brain aging [brain-age gap (BAG)]. Design: One hundred and four PWH (HIV RNA <50 copies/ml) and 42 PWoH provided blood samples and completed a cardiovascular risk score calculator, neuroimaging, and cognitive testing. Method: Plasma NfL was compared between PWoH and PWH and assessed for relationships with age, HIV clinical markers, cardiovascular disease risk, cognition, and BAG (difference between a brain-predicted age and chronological age). Results: Plasma NfL was not significantly different between PWoH and PWH. Higher NfL related to increasing age in both groups. Plasma NfL was not associated with typical HIV disease variables. Within PWH, NfL was higher with higher cardiovascular risk, cognitive impairment and a greater BAG. Conclusion: Virally suppressed PWH who are cognitively normal likely do not have significant ongoing neurodegeneration, as evidenced by similar plasma NfL compared with PWoH. However, NfL may represent a biomarker of cognitive impairment and brain aging in PWH. Further research examining NfL with longitudinal cognitive decline is needed to understand this relationship more fully. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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