Watch-and-wait strategy vs. resection in patients with radiologic complete response after conversion therapy for initially unresectable hepatocellular carcinoma: a propensity score-matching comparative study.

Autor:	Li B; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Liver Surgery., Wang C; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Liver Surgery., He W; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Liver Surgery., Qiu J; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Liver Surgery., Zheng Y; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Liver Surgery., Zou R; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Ultrasound., Lin Z; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Liver Surgery., Shi Y; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Liver Surgery., Yuan Y; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Liver Surgery., Zhang R; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Medical Imaging., Zhang C; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Pathology, Sun Yat-Sen University Cancer Center, Guangzhou., Chen M; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Liver Surgery., Lau WY; Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, People's Republic of China., Yuan Y; State Key Laboratory of Oncology in South China and Collaborative Innovation Center for Cancer Medicine.; Department of Liver Surgery.
Jazyk:	angličtina
Zdroj:	International journal of surgery (London, England) [Int J Surg] 2024 May 01; Vol. 110 (5), pp. 2545-2555. Date of Electronic Publication: 2024 May 01.
DOI:	10.1097/JS9.0000000000001155
Abstrakt:	Background: The optimal subsequent management for patients with initially unresectable hepatocellular carcinoma (uHCC) who have achieved complete response (CR) following conversion therapy remains unclear. This study aims to evaluate the feasibility and outcomes of the watch-and-wait (W-W) strategy versus surgical resection (SR) for these patients. Materials and Methods: This retrospective study reviewed patients with initially uHCC who underwent conversion therapy employing transarterial therapies combined with or without systemic therapies. Radiologic CR (rCR), clinical CR (cCR), and pathologic CR (pCR) were evaluated. Overall survival (OS) and progression-free survival (PFS) were compared between the W-W and SR groups. Results: Among 1880 patients with uHCC who underwent conversion therapy, 207 (11.0%) achieved rCR. Finally, we enrolled 149 patients meeting the inclusion criteria, including 74 receiving W-W strategy and 75 undergoing SR. Among the 149 patients with rCR, the W-W group demonstrated comparable 3-year OS rates to the SR group (80.9 vs 83.1%, P =0.77), but demonstrated inferior PFS rates (14.4 vs 46.5%, P =0.002). These results remained consistent after propensity score matching. For the 57 patients who achieved cCR, the W-W group exhibited comparable 3-year OS (88.1 vs 87.9%, P =0.89) and PFS rates (27.8 vs 40.8%, P =0.34) compared to SR group. Among the 75 patients in the SR group, 31 (41.3%) achieved pCR and 44 (58.7%) reached non-pCR. When compared with patients with pCR, those who achieved rCR in the W-W group showed comparable OS but inferior PFS rates. Moreover, patients who achieved rCR in the W-W group displayed both comparable OS and PFS rates to those with non-pCR. Conclusion: The W-W strategy offered comparable survival outcomes to SR in patients with initially uHCC who achieved rCR or cCR after conversion therapy. For these patients, the W-W strategy could be offered as an alternative treatment option. (Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc.)
Databáze:	MEDLINE
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