| Autor: |
Escuder-Vieco D; Neonatology Department. Hospital Universitario 12 de Octubre., Gomis Muñoz P; Department of Pharmacy. Hospital Universitario 12 de Octubre., Hernández Ramos JA; Department of Pharmacy. Hospital Universitario 12 de Octubre., Bruni Montero MÁ; Department of Pharmacy. Hospital Universitario 12 de Octubre., Bergón Sendín E; Department of Pharmacy. Hospital Universitario 12 de Octubre., de la Cruz Bértolo J; Neonatology Department. Hospital Universitario 12 de Octubre., Bustos Lozano G; Neonatology Department. Hospital Universitario 12 de Octubre. |
| Jazyk: |
angličtina |
| Zdroj: |
Nutricion hospitalaria [Nutr Hosp] 2024 Jun 27; Vol. 41 (3), pp. 547-553. |
| DOI: |
10.20960/nh.04931 |
| Abstrakt: |
Introduction: Introduction: the stability of total parenteral nutrition admixtures for neonates (TPNAn) has been questioned in relation to the interaction between calcium and fish oil emulsions. Aim: the aim of this study was to check the stability (particle size < 1 µm) of different individualized TPNAn prepared with fish-oil emulsion and containing calcium at concentrations ranging from 10 to 20 mmol/L. Methods: admixtures analyzed: twelve different formulations with SMOFlipid® 20 % (conserved for 24 h and for 96 h), three formulations with Lipoplus® 20 % (conserved for 96 h) and three formulations with SMOFlipid® 20 % with Multi-12K1® Pediatric (conserved for 96 h). Two bags were compounded for each formulation and conservation period. Measurements on each admixture bag: particle standardized diameter by laser diffraction technique and pH by a calibrated pH-meter. Data analysis with mixed linear regression models. Results: maximum particle size was < 0.8 µm for all investigated admixtures. Lipid concentration of 5 g/L and sodium and potassium concentration of 100 mmol/L slightly increased the proportion of particles > 0.6 µm. Ninety six hours storage also increased the percentage of particles > 0.6 µm (+0.143 ± 0.07; p = 0.038) but did not influence other parameters. No association with calcium composition was observed. Amino acid content was inversely correlated with pH (-0.83; p < 0.0001). Conclusions: the studied individualized parenteral nutrition admixtures for newborns that contain fish oil emulsions and meet cation requirements are stable for at least 96 hours. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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