Survival of bronchopulmonary cancers according to radon exposure.

Autor:	Dessemon J; Département Prévention Cancer Environnement, Center Léon Bérard, Lyon, France.; Faculté de Médecine Lyon Est, Université de Lyon, Lyon, France., Perol O; Département Prévention Cancer Environnement, Center Léon Bérard, Lyon, France.; Inserm UMR1296, 'Radiation: Defense, Health Environment,' Center Léon Bérard, Lyon, France., Chauvel C; Center of Excellence in Respiratory Pathogens (CERP), Hospices Civils de Lyon, Lyon, France.; Centre International de Recherche en Infectiologie (CIRI), Inserm U1111, CNRS UMR5308, ENS de Lyon, Université Claude Bernard Lyon 1, Lyon, France., Noelle H; Département Prévention Cancer Environnement, Center Léon Bérard, Lyon, France.; Faculté de Médecine Lyon Est, Université de Lyon, Lyon, France., Coudon T; Département Prévention Cancer Environnement, Center Léon Bérard, Lyon, France.; Inserm UMR1296, 'Radiation: Defense, Health Environment,' Center Léon Bérard, Lyon, France., Grassot L; Département Prévention Cancer Environnement, Center Léon Bérard, Lyon, France.; Inserm UMR1296, 'Radiation: Defense, Health Environment,' Center Léon Bérard, Lyon, France., Foray N; Inserm UMR1296, 'Radiation: Defense, Health Environment,' Center Léon Bérard, Lyon, France., Belladame E; Département Prévention Cancer Environnement, Center Léon Bérard, Lyon, France.; Inserm UMR1296, 'Radiation: Defense, Health Environment,' Center Léon Bérard, Lyon, France., Fayette J; Département de Cancérologie Médicale, Center Léon Bérard, Lyon, France., Fournie F; Département Interdisciplinaire de Soins de Support du Patient en Oncologie, Center Léon Bérard, Lyon, France., Swalduz A; Département de Cancérologie Médicale, Center Léon Bérard, Lyon, France., Neidhart EM; Département de Cancérologie Médicale, Center Léon Bérard, Lyon, France., Saintigny P; Département de Cancérologie Médicale, Center Léon Bérard, Lyon, France., Tabutin M; Département de Chirurgie Cancérologique, Center Léon Bérard, Lyon, France., Boussageon M; Inserm UMR1296, 'Radiation: Defense, Health Environment,' Center Léon Bérard, Lyon, France., Gomez F; Département de Santé Publique, Center Léon Bérard, Lyon, France., Avrillon V; Département de Cancérologie Médicale, Center Léon Bérard, Lyon, France., Perol M; Département de Cancérologie Médicale, Center Léon Bérard, Lyon, France., Charbotel B; Université de Lyon, Université Lyon 1, Université Gustave Eiffel-Ifsttar, Umrestte, UMR, Lyon, France.; CRPPE-Lyon, Center Régional de Pathologies Professionnelles et Environnementales de Lyon, Center Hospitalier Lyon Sud, Hospices Civils de Lyon, Lyon, France., Fervers B; Département Prévention Cancer Environnement, Center Léon Bérard, Lyon, France.; Inserm UMR1296, 'Radiation: Defense, Health Environment,' Center Léon Bérard, Lyon, France.
Jazyk:	angličtina
Zdroj:	Frontiers in public health [Front Public Health] 2024 Jan 24; Vol. 11, pp. 1306455. Date of Electronic Publication: 2024 Jan 24 (Print Publication: 2023).
DOI:	10.3389/fpubh.2023.1306455
Abstrakt:	Introduction: Residential exposure is estimated to be responsible for nearly 10% of lung cancers in 2015 in France, making it the second leading cause, after tobacco. The Auvergne-Rhône-Alpes region, in the southwest of France, is particularly affected by this exposure as 30% of the population lives in areas with medium or high radon potential. This study aimed to investigate the impact of radon exposure on the survival of lung cancer patients. Methods: In this single-center study, patients with a histologically confirmed diagnosis of lung cancer, and newly managed, were prospectively included between 2014 and 2020. Univariate and multivariate survival analyses were carried out using a non-proportional risk survival model to consider variations in risk over time. Results: A total of 1,477 patients were included in the analysis. In the multivariate analysis and after adjustment for covariates, radon exposure was not statistically associated with survival of bronchopulmonary cancers (HR = 0.82 [0.54-1.23], HR = 0.92 [0.72-1.18], HR = 0.95 [0.76-1.19] at 1, 3, and 5 years, respectively, for patients residing in category 2 municipalities; HR = 0.87 [0.66-1.16], HR = 0.92 [0.76-1.10], and HR = 0.89 [0.75-1.06] at 1, 3, and 5 years, respectively, for patients residing in category 3 municipalities). Discussion: Although radon exposure is known to increase the risk of lung cancer, in the present study, no significant association was found between radon exposure and survival of bronchopulmonary cancers. Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. The author(s) declared that they were an editorial board member of Frontiers, at the time of submission. This had no impact on the peer review process and the final decision. (Copyright © 2024 Dessemon, Perol, Chauvel, Noelle, Coudon, Grassot, Foray, Belladame, Fayette, Fournie, Swalduz, Neidhart, Saintigny, Tabutin, Boussageon, Gomez, Avrillon, Perol, Charbotel and Fervers.)
Databáze:	MEDLINE
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