Assessment of novel POCT to evaluate liver function.
| Autor: | Minea C; Department of Clinical Biochemistry, Hospital Universitario Fundación Jiménez Díaz, Madrid, Spain., Gruson D; Department of Clinical Biochemistry, Cliniques Universitaires St-Luc, Université Catholique de Louvain, Brussels, Belgium.; Pôle de recherche en Endocrinologie, Diabète et Nutrition, Institut de Recherche Expérimentale et Clinique, Cliniques Universitaires St-Luc, Université Catholique de Louvain, Brussels, Belgium. |
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| Jazyk: | angličtina |
| Zdroj: | Practical laboratory medicine [Pract Lab Med] 2024 Jan 30; Vol. 39, pp. e00367. Date of Electronic Publication: 2024 Jan 30 (Print Publication: 2024). |
| DOI: | 10.1016/j.plabm.2024.e00367 |
| Abstrakt: | Objectives: Point of care testing (POCT) offers the possibility of near bedside patient testing with a reduction of the turn-around time of analysis. The aim of our study was to determine the analytical performances and usability of a recently developed POCT device for the measurement of tests related to liver function. We evaluated the performance of a liver tests panel performed on the LINX EVO® POCT device. Design and Methods: The imprecision was determined with the Bio-Rad Liquichek Unassayed Chemistry Control. Method comparison was performed with a Cobas® 8000 analyzer. Samples from twenty healthy volunteers were used to verify the reference intervals. Furthermore, practicality was assessed by the healthcare staff handling the POCT device through a dedicated questionnaire. Results: The imprecision observed was matching the criteria for the in-lab assay with only one exception, globulin, with an observed imprecision of 6.3 % and a criteria of 5.7 %. With the exception of total and direct bilirubin, the POCT method showed good agreement with the in-lab methods. The verification of reference intervals showed that more than 90 % of the healthy volunteer values were included into the reference interval claimed by the manufacturer except for glucose and globulin. The POCT practicality questionnaire was satisfying overall for users. Conclusions: Our study showed very good analytical performances overall for the liver test panel performed on the LINX EVO® POCT instrument. Competing Interests: We confirm that this work is original and has not been published elsewhere, nor is it currently under consideration for publication elsewhere. In this paper, we report on a new POCT device that offers quick results of several parameters of the liver function. This is significant because aassuring the quality of the results of POCT devices should be provided by the laboratory personnel already skilled in the field. We believe that this manuscript is appropriate for publication by PRACTICAL LABORATORY MEDICINE because it focuses on analytical performance oof a point of care tests panel that can be used for diagnosis, prognosis, treatment and therapy, and monitoring of disease. We have no conflicts of interest to disclose. We have not receive relevant financial support (for example patent ownership, stock ownership, consultancies, and speaker's fees). And we don't have any personal, political, intellectual, or religious interests. (© 2024 The Authors.) |
| Databáze: | MEDLINE |
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