Introduction of Aedes aegypti mosquitoes carrying w AlbB Wolbachia sharply decreases dengue incidence in disease hotspots.

Autor:	Hoffmann AA; Pest and Environmental Research Group, School of BioSciences, The University of Melbourne, Parkville, VIC 3010, Australia., Ahmad NW; Medical Entomology Unit, Infectious Disease Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur 50588, Malaysia., Keong WM; Vector Borne Disease Control Section, Disease Control Division, Ministry of Health Malaysia, Complex E, Block E10, Persiaran Sultan Sallahuddin Abdul Aziz Shah, Presint 1, Putrajaya 62000, Malaysia., Ling CY; Biomedical Museum Unit, Special Resource Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur 50588, Malaysia., Ahmad NA; Medical Entomology Unit, Infectious Disease Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur 50588, Malaysia., Golding N; Telethon Kids Institute, Perth Children's Hospital, Nedlands, WA 6009, Australia.; Curtin School of Population Health, Curtin University, Bentley, WA 6845, Australia.; Melbourne School of Population and Global Health, University of Melbourne, Parkville, VIC 3052, Australia., Tierney N; Telethon Kids Institute, Perth Children's Hospital, Nedlands, WA 6009, Australia.; Curtin School of Population Health, Curtin University, Bentley, WA 6845, Australia., Jelip J; Vector Borne Disease Control Section, Disease Control Division, Ministry of Health Malaysia, Complex E, Block E10, Persiaran Sultan Sallahuddin Abdul Aziz Shah, Presint 1, Putrajaya 62000, Malaysia., Putit PW; Vector Borne Disease Control Section, Disease Control Division, Ministry of Health Malaysia, Complex E, Block E10, Persiaran Sultan Sallahuddin Abdul Aziz Shah, Presint 1, Putrajaya 62000, Malaysia., Mokhtar N; Vector Borne Disease Control Section, Disease Control Division, Ministry of Health Malaysia, Complex E, Block E10, Persiaran Sultan Sallahuddin Abdul Aziz Shah, Presint 1, Putrajaya 62000, Malaysia., Sandhu SS; Petaling District Health Office, Ministry of Health Malaysia, SS 6, Petaling Jaya 47301, Selangor, Malaysia., Ming LS; Petaling District Health Office, Ministry of Health Malaysia, SS 6, Petaling Jaya 47301, Selangor, Malaysia., Khairuddin K; Petaling District Health Office, Ministry of Health Malaysia, SS 6, Petaling Jaya 47301, Selangor, Malaysia., Denim K; Vector Borne Disease Control Section, Disease Control Division, Ministry of Health Malaysia, Complex E, Block E10, Persiaran Sultan Sallahuddin Abdul Aziz Shah, Presint 1, Putrajaya 62000, Malaysia., Rosli NM; Health Department of Federal Territory of Kuala Lumpur & Putrajaya, Jalan Cenderasari, Kuala Lumpur 50590, Malaysia., Shahar H; Health Department of Federal Territory of Kuala Lumpur & Putrajaya, Jalan Cenderasari, Kuala Lumpur 50590, Malaysia., Omar T; Health Department of Federal Territory of Kuala Lumpur & Putrajaya, Jalan Cenderasari, Kuala Lumpur 50590, Malaysia., Ridhuan Ghazali MK; Medical Entomology Unit, Infectious Disease Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur 50588, Malaysia., Aqmar Mohd Zabari NZ; Medical Entomology Unit, Infectious Disease Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur 50588, Malaysia., Abdul Karim MA; Medical Entomology Unit, Infectious Disease Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur 50588, Malaysia., Saidin MI; Medical Entomology Unit, Infectious Disease Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur 50588, Malaysia., Mohd Nasir MN; Medical Entomology Unit, Infectious Disease Research Centre, Institute for Medical Research, Jalan Pahang, Kuala Lumpur 50588, Malaysia., Aris T; Institute for Medical Research, National Institutes of Health, Ministry of Health Malaysia, Jalan Setia Murni U13/52, Seksyen U13, Shah Alam 40170, Selangor, Malaysia., Sinkins SP; MRC-University of Glasgow Centre for Virus Research, Glasgow, UK.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Jan 18; Vol. 27 (2), pp. 108942. Date of Electronic Publication: 2024 Jan 18 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.108942
Abstrakt:	Partial replacement of resident Aedes aegypti mosquitoes with introduced mosquitoes carrying certain strains of inherited Wolbachia symbionts can result in transmission blocking of dengue and other viruses of public health importance. Wolbachia strain w AlbB is an effective transmission blocker and stable at high temperatures, making it particularly suitable for hot tropical climates. Following trial field releases in Malaysia, releases using w AlbB Ae. aegypti have become operationalized by the Malaysian health authorities. We report here on an average reduction in dengue fever of 62.4% (confidence intervals 50-71%) in 20 releases sites when compared to 76 control sites in high-rise residential areas. Importantly the level of dengue reduction increased with Wolbachia frequency, with 75.8% reduction (61-87%) estimated at 100% Wolbachia frequency. These findings indicate large impacts of w AlbB Wolbachia invasions on dengue fever incidence in an operational setting, with incidence expected to further decrease as wider areas are invaded. Competing Interests: The authors declare that they do not have conflicting interests. (© 2024 The Author(s).)
Databáze:	MEDLINE
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