Imaging characterization of paediatric tumours with the neurotrophic tyrosine receptor kinase fusion transcript.

Autor:	Hermann AL; Department of Imaging, Institut Curie, PSL University, Paris, 75005, France., Lemelle L; SIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), Institut Curie, PSL University, Paris, 75005, France., Pierron G; Department of Somatic Genetics, Institut Curie, PSL University, Paris, 75005, France., Gauthier A; Department of Pathology, Institut Curie, PSL University, Paris, 75005, France., Nicolas N; Department of Imaging, Institut Curie, PSL University, Paris, 75005, France., Cardoen L; Department of Imaging, Institut Curie, PSL University, Paris, 75005, France., Moalla S; Department of Imaging, Gustave Roussy Cancer Center, Villejuif, 94805, France., Petit P; Department of Imaging, Assistance Publique des Hôpitaux de Marseille, Hôpital de La Timone, Marseille, 13005, France., Morel B; Department of Pediatric Radiology, CHRU Hôpitaux de Tours, Tours, 37000, France., Ducou Le Pointe H; Department of Pediatric Radiology, Assistance Publique des Hôpitaux de Paris, Hôpital Armand Trousseau, Paris, 75012, France., Hassani A; Department of Pediatric Radiology, CHU Rouen, Rouen, 76000, France., Fréneaux P; Department of Pathology, Institut Curie, PSL University, Paris, 75005, France., Guillemot D; Department of Somatic Genetics, Institut Curie, PSL University, Paris, 75005, France., Carton M; Department of Biostatistics, Institut Curie, PSL University, Paris, 75005, France., Corradini N; Department of Pediatric Oncology and Hematology, Centre Léon Bérard, Lyon, 69008, France., Rome A; Department of Pediatric Oncology, Assistance Publique des Hôpitaux de Marseille, Hôpital de la Timone, Marseille, 13005, France., Castex MP; Department of Pediatric Oncology and Hematology, CHU Toulouse, Toulouse, 31300, France., Defachelles AS; Department of Pediatric Oncology, Oscar Lambret Center, Lille, 59000, France., Schleiermacher G; SIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), Institut Curie, PSL University, Paris, 75005, France., Berlanga P; Department of Pediatric and Adolescent Oncology, Gustave Roussy Cancer Center, INSERM U1015, Université Paris-Saclay, Villejuif, 94805, France., Delattre O; SIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), Institut Curie, PSL University, Paris, 75005, France.; Department of Somatic Genetics, Institut Curie, PSL University, Paris, 75005, France., Orbach D; SIREDO Oncology Center (Care, Innovation and Research for Children and AYA with Cancer), Institut Curie, PSL University, Paris, 75005, France., Brisse HJ; Department of Imaging, Institut Curie, PSL University, Paris, 75005, France.
Jazyk:	angličtina
Zdroj:	The British journal of radiology [Br J Radiol] 2024 Mar 28; Vol. 97 (1156), pp. 734-743.
DOI:	10.1093/bjr/tqae016
Abstrakt:	Objectives: The neurotrophic tyrosine receptor kinase (NTRK) fusion transcript (FT) is a major genetic landmark of infantile fibrosarcoma (IFS) and cellular congenital mesoblastic nephroma (cCMN) but is also described in other tumours. The recent availability of NTRK-targeted drugs enhances the need for better identification. We aimed to describe the anatomic locations and imaging features of tumours with NTRK-FT in children. Case Series: Imaging characteristics of NTRK-FT tumours of 41 children (median age: 4 months; 63% <1 year old; range: 0-188) managed between 2001 and 2019 were retrospectively analysed. The tumours were located in the soft tissues (n = 24, including 19 IFS), kidneys (n = 9, including 8 cCMN), central nervous system (CNS) (n = 5), lung (n = 2), and bone (n = 1). The tumours were frequently deep-located (93%) and heterogeneous (71%) with necrotic (53%) or haemorrhagic components (29%). Although inconstant, enlarged intratumoural vessels were a recurrent finding (70%) with an irregular distribution (63%) in the most frequent anatomical locations. Conclusion: Paediatric NTRK-FT tumours mainly occur in infants with very variable histotypes and locations. Rich and irregular intra-tumoural vascularization are recurrent findings. Advances in Knowledge: Apart from IFS of soft tissues and cCMN of the kidneys, others NTRK-FT tumours locations have to be known, as CNS tumours. Better knowledge of the imaging characteristics may help guide the pathological and biological identification. (© The Author(s) 2024. Published by Oxford University Press on behalf of the British Institute of Radiology. All rights reserved. For permissions, please email: journals.permissions@oup.com.)
Databáze:	MEDLINE
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