| Autor: |
Wang X; School of Pharmacy, Liaoning University of Traditional Chinese Medicine., Zhao M; School of Pharmacy, Liaoning University of Traditional Chinese Medicine., Ju C; School of Pharmacy, Liaoning University of Traditional Chinese Medicine., Gao H; School of Pharmacy, Liaoning University of Traditional Chinese Medicine., Wang W; School of Pharmacy, Liaoning University of Traditional Chinese Medicine. |
| Jazyk: |
angličtina |
| Zdroj: |
Chemical & pharmaceutical bulletin [Chem Pharm Bull (Tokyo)] 2024 Mar 06; Vol. 72 (3), pp. 280-285. Date of Electronic Publication: 2024 Feb 07. |
| DOI: |
10.1248/cpb.c23-00578 |
| Abstrakt: |
This study investigated the hepatoprotective effects of Juncus effusus (J. effusus) and Carbonized J. effusus against liver injury caused by D-galactosamine (D-GalN) in mice. J. effusus and Carbonized J. effusus were administered by gavage once daily starting seven days before the D-GalN treatment. The results of the study indicated that J. effusus and Carbonized J. effusus suppressed the D-GalN-induced generation of serum alanine transaminase (ALT), aspartate aminotransferase (AST), hepatic malondialdehyde (MDA) and tumor necrosis factor-alpha (TNF-α) was observed. The values of superoxide dismutase (SOD) exhibited an increase. In addition, J. effusus and Carbonized J. effusus promoted the protein expression of nuclear factor erythroid 2-related factor 2 (Nrf2), NADPH quinone oxidoreductase-1 (NQO-1), heme oxygenase-1 (HO-1) as well as the mRNA expression of Nrf2, HO-1, NQO-1 and Glutamate cysteine ligase catalytic subunit (GCLC). The compressed Carbonized J. effusus demonstrated the optimum impact. These results suggest that J. effusus and Carbonized J. effusus protect against D-GalN-induced acute liver injury through the activation of the Nrf2 pathway. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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