Enhancing anti-amyloidogenic properties and antioxidant effects of Scutellaria baicalensis polyphenols through novel nanoparticle formation.

Autor: Jalili S; Research Center for Life and Health Sciences and Biotechnology of the Police, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran 1417944661, Iran; Institute of Police Equipment and Technologies, Policing Sciences and Social Studies Research Institute, Tehran 1417944661, Iran., Panji M; Research Center for Life and Health Sciences and Biotechnology of the Police, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran 1417944661, Iran., Mahdavimehr M; Institute of Biochemistry and Biophysics, University of Tehran, Tehran 1417614335, Iran. Electronic address: m.mahdavimehr@ut.ac.ir., Mohseni Ahangar A; School of Metallurgy & Materials Engineering, Iran University of Science and Technology (IUST), Narmak, Tehran 16846, Iran., Shirzad H; Research Center for Life and Health Sciences and Biotechnology of the Police, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran 1417944661, Iran., Mousavi Nezhad SA; Research Center for Life and Health Sciences and Biotechnology of the Police, Directorate of Health, Rescue & Treatment, Police Headquarter, Tehran 1417944661, Iran., Palhano FL; Instituto de Bioquímica Médica, Programa de Biologia Estrutural, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-590, Brazil. Electronic address: palhano@bioqmed.ufrj.br.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2024 Mar; Vol. 262 (Pt 1), pp. 130003. Date of Electronic Publication: 2024 Feb 05.
DOI: 10.1016/j.ijbiomac.2024.130003
Abstrakt: Protein aggregation and oxidative stress have gained significant research attention due to their association with a group of diseases known as amyloidosis. Among the strategies developed to prevent amyloidosis, utilization of polyphenols stands out as one of the most commonly employed approaches. Scutellaria baicalensis is renowned as one of the foremost herbal sources of polyphenols. In this study, we employed a direct oxidative pyrolysis method for polymerizing S. baicalensis's polyphenols (SBPPs) after their extraction, resulting in the formation of novel SBPPs nanoparticles. Upon polymerization, SBPPs nanoparticles showed remarkable properties including heightened water solubility, increased surface area, modified surface functional groups, and enhanced stability. As a result of these diverse factors, there was a considerable enhancement in the anti-amyloidogenic properties and antioxidant effects of SBPPs nanoparticles compared to its bulk form. The fibrillation kinetics, AFM images, and cytotoxicity assays strongly indicate that SBPPs nanoparticles are more effective than SBPPs at preventing amyloid fibril formation and associated cell toxicity. Additionally, SBPPs nanoparticles demonstrated more effective prevention of reactive oxygen species (ROS) production. In conclusion, the use of SBPPs in nanoparticle form presents a promising strategy to enhance anti-amyloidogenic properties, mitigate oxidative stress, and offer potential therapeutic benefits for amyloidosis-related diseases.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: