Homocysteine serum levels in patients with ruptured and unruptured intracranial aneurysms: a case-control study.

Autor:	Mota Telles JP; Universidade de São Paulo, Faculdade de Medicina, Departamento de Neurologia, São Paulo SP, Brazil., Rosi Junior J; Universidade de São Paulo, Faculdade de Medicina, Divisão de Neurocirurgia, São Paulo SP, Brazil., Yamaki VN; Universidade de São Paulo, Faculdade de Medicina, Divisão de Neurocirurgia, São Paulo SP, Brazil., Rabelo NN; Universidade de São Paulo, Faculdade de Medicina, Divisão de Neurocirurgia, São Paulo SP, Brazil., Teixeira MJ; Universidade de São Paulo, Faculdade de Medicina, Divisão de Neurocirurgia, São Paulo SP, Brazil., Figueiredo EG; Universidade de São Paulo, Faculdade de Medicina, Divisão de Neurocirurgia, São Paulo SP, Brazil.
Jazyk:	angličtina
Zdroj:	Arquivos de neuro-psiquiatria [Arq Neuropsiquiatr] 2024 Feb; Vol. 82 (2), pp. 1-6. Date of Electronic Publication: 2024 Feb 07.
DOI:	10.1055/s-0044-1779270
Abstrakt:	Background: There is very few data regarding homocysteine's influence on the formation and rupture of intracranial aneurysms. Objective: To compare homocysteine levels between patients with ruptured and unruptured intracranial aneurysms, and to evaluate possible influences of this molecule on vasospasm and functional outcomes. Methods: This is a retrospective, case-control study. We evaluated homocysteinemia differences between patients with ruptured and unruptured aneurysms; and the association of homocysteine levels with vasospasm and functional outcomes. Logistic regressions were performed. Results: A total of 348 participants were included: 114 (32.8%) with previous aneurysm rupture and 234 (67.2%) with unruptured aneurysms. Median homocysteine was 10.75µmol/L (IQR = 4.59) in patients with ruptured aneurysms and 11.5µmol/L (IQR = 5.84) in patients with unruptured aneurysms. No significant association was detected between homocysteine levels and rupture status (OR = 0.99, 95% CI = 0.96-1.04). Neither mild (>15µmol/L; OR = 1.25, 95% CI 0.32-4.12) nor moderate (>30µmol/L; OR = 1.0, 95% CI = 0.54-1.81) hyperhomocysteinemia demonstrated significant correlations with ruptured aneurysms. Neither univariate (OR = 0.86; 95% CI 0.71-1.0) nor multivariable age-adjusted (OR = 0.91; 95% CI = 0.75-1.05) models evidenced an association between homocysteine levels and vasospasm. Homocysteinemia did not influence excellent functional outcomes at 6 months (mRS≤1) (OR = 1.04; 95% CI = 0.94-1.16). Conclusion: There were no differences regarding homocysteinemia between patients with ruptured and unruptured intracranial aneurysms. In patients with ruptured aneurysms, homocysteinemia was not associated with vasospasm or functional outcomes. Competing Interests: There is no conflict of interest to declare. (The Author(s). This is an open access article published by Thieme under the terms of the Creative Commons Attribution 4.0 International License, permitting copying and reproduction so long as the original work is given appropriate credit (https://creativecommons.org/licenses/by/4.0/).)
Databáze:	MEDLINE
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