CBD treatment following early life seizures alters orbitofrontal-striatal signaling during adulthood.

Autor: Cashen NA; Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT, United States., Kloc ML; Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT, United States., Pressman D; Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT, United States., Liebman SA; Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT, United States., Holmes GL; Department of Neurological Sciences, University of Vermont, Larner College of Medicine, Burlington, VT, United States. Electronic address: gregory.holmes@med.uvm.edu.
Jazyk: angličtina
Zdroj: Epilepsy & behavior : E&B [Epilepsy Behav] 2024 Mar; Vol. 152, pp. 109638. Date of Electronic Publication: 2024 Feb 06.
DOI: 10.1016/j.yebeh.2024.109638
Abstrakt: Obsessive compulsive disorder (OCD) is a comorbid condition of epilepsy and often adds to the burden of epilepsy. Both OCD and epilepsy are disorders of hyperexcitable circuits. Fronto-striatal circuit dysfunction is implicated in OCD. Prior work in our laboratory has shown that in rat pups following a series of flurothyl-induced early life seizures (ELS) exhibit frontal-lobe dysfunction along with alterations in electrographic temporal coordination between the orbitofrontal cortex (OFC) and dorsomedial striatum (DMS), circuits implicated in OCD. Here, we studied the effects of ELS in male and female rat pups on OCD-like behaviors as adults using the marble burying test (MBT). Because cannabidiol (CBD) is an effective antiseizure medication and has shown efficacy in the treatment of individuals with OCD, we also randomized rats to CBD or vehicle treatment following ELS to determine if CBD had any effect on OCD-like behaviors. While the flurothyl model of ELS did not induce OCD-like behaviors, as measured in the MBT, ELS did alter neural signaling in structures implicated in OCD and CBD had sex-dependent effects of temporal coordination in a way which suggests it may have a beneficial effect on epilepsy-related OCD.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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