Maternal and paternal licit and illicit drug use, smoking and drinking and autism spectrum disorder.

Autor:	Costa AA; Superintendência Regional de Saúde de Montes Claros. R. Corrêa Machado 1333, Vila Santa Maria. 39400-090 Montes Claros MG Brasil. bandinhaandrade@gmail.com., Almeida MTC; Departamento de Fisiopatologia, Centro de Ciências Biológicas, Universidade Estadual de Montes Claros. Montes Claros MG Brasil., Maia FA; Departamento de Fisiopatologia, Centro de Ciências Biológicas, Universidade Estadual de Montes Claros. Montes Claros MG Brasil., Rezende LF; Departamento de Fisiopatologia, Centro de Ciências Biológicas, Universidade Estadual de Montes Claros. Montes Claros MG Brasil., Saeger VSA; Comviver - Núcleo de Desenvolvimento, Pesquisa e Inclusão. Montes Claros MG Brasil., Oliveira SLN; Comviver - Núcleo de Desenvolvimento, Pesquisa e Inclusão. Montes Claros MG Brasil.; Faculdades FUNORTE. Montes Claros MG Brasil., Mangabeira GL; Faculdades FUNORTE. Montes Claros MG Brasil.; Liv Psiquiatria. Montes Claros MG Brasil., Silveira MF; Programa de Pós-Graduação em Cuidados Primários de Saúde, Universidade Estadual de Montes Claros. Montes Claros MG Brasil.
Jazyk:	Portuguese; English
Zdroj:	Ciencia & saude coletiva [Cien Saude Colet] 2024 Feb; Vol. 29 (2), pp. e01942023. Date of Electronic Publication: 2023 May 24.
DOI:	10.1590/1413-81232024292.01942023
Abstrakt:	The aim of this study was to investigate the association between maternal and paternal licit and illicit drug use, smoking and drinking and autism spectrum disorder (ASD). We conducted a case-control study with children and adolescents diagnosed with ASD and neurotypical individuals. The data were collected using a semi-structured questionnaire administered during interviews with the children's mothers or guardians. The following variables were analyzed: child sex and age; maternal and parental age; use of medicines before and during pregnancy; classes of medicines used during pregnancy; maternal and paternal smoking; maternal and paternal drinking; maternal and paternal illicit drug use. The data were analyzed using logistic regression and crude and adjusted odds ratios (OR). After adjustment, the results showed an association between maternal use of antipyretics/pain killers during pregnancy (OR = 2.26; 95%CI 1.29-3.95; p < 0.040) and ASD. No association was found between maternal and paternal smoking, drinking and illicit drug use before and during pregnancy and ASD. The findings suggest that the development of ASD is influenced by environmental factors.
Databáze:	MEDLINE
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