Host gastric corpus microenvironment facilitates Ascaris suum larval hatching and infection in a murine model.

Autor: Wu Y; Department of Pediatrics, Division of Pediatric Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America., Adeniyi-Ipadeola G; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America., Adkins-Threats M; Department of Medicine, Section of Gastroenterology, Baylor College of Medicine, Houston, Texas, United States of America.; Departments of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, United States of America.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America., Seasock M; Department of Medicine, Immunology, Pathology, Baylor College of Medicine, Houston, Texas, United States of America., Suarez-Reyes C; Department of Pediatrics, Division of Pediatric Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America., Fujiwara R; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Bottazzi ME; Department of Pediatrics, Division of Pediatric Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.; Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America.; National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America., Song L; Department of Medicine, Immunology, Pathology, Baylor College of Medicine, Houston, Texas, United States of America., Mills JC; Department of Medicine, Section of Gastroenterology, Baylor College of Medicine, Houston, Texas, United States of America.; Departments of Pathology & Immunology, Baylor College of Medicine, Houston, Texas, United States of America.; Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America., Weatherhead JE; Department of Pediatrics, Division of Pediatric Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.; National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, United States of America.; Department of Medicine, Section of Infectious Diseases, Baylor College of Medicine, Houston, Texas, United States of America.
Jazyk: angličtina
Zdroj: PLoS neglected tropical diseases [PLoS Negl Trop Dis] 2024 Feb 07; Vol. 18 (2), pp. e0011930. Date of Electronic Publication: 2024 Feb 07 (Print Publication: 2024).
DOI: 10.1371/journal.pntd.0011930
Abstrakt: Ascariasis (roundworm) is the most common parasitic helminth infection globally and can lead to significant morbidity in children including chronic lung disease. Children become infected with Ascaris spp. via oral ingestion of eggs. It has long been assumed that Ascaris egg hatching and larval translocation across the gastrointestinal mucosa to initiate infection occurs in the small intestine. Here, we show that A. suum larvae hatched in the host stomach in a murine model. Larvae utilize acidic mammalian chitinase (AMCase; acid chitinase; Chia) from chief cells and acid pumped by parietal cells to emerge from eggs on the surface of gastric epithelium. Furthermore, antagonizing AMCase and gastric acid in the stomach decreases parasitic burden in the liver and lungs and attenuates lung disease. Given Ascaris eggs are chitin-coated, the gastric corpus would logically be the most likely organ for egg hatching, though this is the first study directly evincing the essential role of the host gastric corpus microenvironment. These findings point towards potential novel mechanisms for therapeutic targets to prevent ascariasis and identify a new biomedical significance of AMCase in mammals.
Competing Interests: The authors have declared that no competing interests exist.
(Copyright: © 2024 Wu et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)
Databáze: MEDLINE
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