Research progress of Paris polyphylla in the treatment of digestive tract cancers.

Autor: Wang J; Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China., Ni BY; Heilongjiang University of Chinese Medicine, Harbin, China.; The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin, China., Wang J; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China.; Graduate College, Beijing University of Chinese Medicine, Chaoyang, China., Han L; Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China., Ni X; Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China., Wang XM; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China., Cao LC; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China., Sun QH; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China., Han XP; Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China., Cui HJ; Hongqi Hospital of Mudanjiang Medical University, Mudanjiang, China. 18846838608@163.com.
Jazyk: angličtina
Zdroj: Discover. Oncology [Discov Oncol] 2024 Feb 07; Vol. 15 (1), pp. 31. Date of Electronic Publication: 2024 Feb 07.
DOI: 10.1007/s12672-024-00882-9
Abstrakt: Cancer has become one of the most important causes of human death. In particular, the 5 year survival rate of patients with digestive tract cancer is low. Although chemotherapy drugs have a certain efficacy, they are highly toxic and prone to chemotherapy resistance. With the advancement of antitumor research, many natural drugs have gradually entered basic clinical research. They have low toxicity, few adverse reactions, and play an important synergistic role in the combined targeted therapy of radiotherapy and chemotherapy. A large number of studies have shown that the active components of Paris polyphylla (PPA), a common natural medicinal plant, can play an antitumor role in a variety of digestive tract cancers. In this paper, the main components of PPA such as polyphyllin, C 21 steroids, sterols, and flavonoids, amongst others, are introduced, and the mechanisms of action and research progress of PPA and its active components in the treatment of various digestive tract cancers are reviewed and summarized. The main components of PPA have been thoroughly explored to provide more detailed references and innovative ideas for the further development and utilization of similar natural antitumor drugs.
(© 2024. The Author(s).)
Databáze: MEDLINE
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