Comparison and discussion of behavior and pathology of four kinds of cerebral palsy disease models.

Autor: Xu J; Hebei University of Chinese Medicine, Shijiazhuang, China., Yan S; Guangxi Medical University, Nanning, China., Xia C; Hebei University of Chinese Medicine, Shijiazhuang, China., Xue J; Hebei University of Chinese Medicine, Shijiazhuang, China., Yu W; Hebei University of Chinese Medicine, Shijiazhuang, China., Yan Y; Hebei University of Chinese Medicine, Shijiazhuang, China., Yin Z; Hebei University of Chinese Medicine, Shijiazhuang, China.
Jazyk: angličtina
Zdroj: International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience [Int J Dev Neurosci] 2024 Apr; Vol. 84 (2), pp. 143-153. Date of Electronic Publication: 2024 Feb 07.
DOI: 10.1002/jdn.10315
Abstrakt: Explore the differences in behavioral and pathological manifestations of rat models of cerebral palsy made by different methods and discuss what types of studies these models are suitable for. Behavioral evaluation and pathological section observation were used to observe and evaluate the model. Conclusion: except for the absence of data of bilateral common carotid artery ligation rats, the other three methods could all achieve a successful cerebral palsy disease model for both behavioral and pathological. For researchers, the selection of intraperitoneal infection model in pregnant rats or unilateral ischemia and hypoxia model in infant rats is sufficient to meet the experimental needs, whereas the selection of the combined method for modeling does not show enough advantages, which not only causes the waste of financial and human resources but also increases the possibility of experimental error made by intervention factors.
(© 2024 International Society for Developmental Neuroscience.)
Databáze: MEDLINE
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