Clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction as a palatal dressing material compared to Alveogyl: randomized clinical trial.

Autor: Alghriany AA; Department of Oral Medicine, Periodontology, and Diagnosis, Faculty of Dentistry, Assiut University, Assiut, Egypt. alghriany@aun.edu.eg., Ali AU; Department of Pharmaceutics, Faculty of Pharmacy, Merit University, Sohag, Egypt., Khallaf ISA; Pharmacognosy and Natural Products Department, Faculty of Pharmacy, Menoufia University, Shibin Elkom, Egypt., Hassan AS; Department of Pharmaceutics, Faculty of Pharmacy, South Valley University, Qena, Egypt., Sayed MA; Department of Industrial Pharmacy, Faculty of Pharmacy, Assiut University, Assiut, Egypt., Fikry AM; Department of Oral Medicine, Periodontology, and Diagnosis, Faculty of Dentistry, Assiut University, Assiut, Egypt.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2024 Feb 06; Vol. 14 (1), pp. 3067. Date of Electronic Publication: 2024 Feb 06.
DOI: 10.1038/s41598-024-53511-4
Abstrakt: This study assessed the clinical effectiveness of orange peel polymethoxy-flavonoids rich fraction (OPMF) solid dispersion as a palatal dressing material, compared with Alveogyl, in a randomized clinical trial. After harvesting free gingival grafts for 18 patients in three groups, the donor site in group I received OPMF; group II received Alveogyl; and group III received placebo dough material. The visual analog scale (VAS) pain score in group I showed the lowest value in week one without a significant difference. In week 2, there was a substantial decrease in pain in group I compared to group III. Week 4 showed reduced pain scores in all groups without significant differences. The results of the number of analgesic pills revealed, after 1 week, the lowest number of pills consumed in group I, with a considerable difference compared to group III. Healing process results showed that group I had the highest healing values in each interval, with a significant difference between group I and group III at 1 and 2 weeks. Color matching parameter showed slight differences between the groups' readings in favor of group I in all intervals without a statistically significant difference. The results suggest OPMF as a palatal dressing material that facilitates hemostasis, pain relief, and palatal wound healing.
(© 2024. The Author(s).)
Databáze: MEDLINE
Externí odkaz: