Sirtuins in kidney health and disease.

Autor: Perico L; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy., Remuzzi G; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy., Benigni A; Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy. ariela.benigni@marionegri.it.
Jazyk: angličtina
Zdroj: Nature reviews. Nephrology [Nat Rev Nephrol] 2024 May; Vol. 20 (5), pp. 313-329. Date of Electronic Publication: 2024 Feb 06.
DOI: 10.1038/s41581-024-00806-4
Abstrakt: Sirtuins (SIRTs) are putative regulators of lifespan in model organisms. Since the initial discovery that SIRTs could promote longevity in nematodes and flies, the identification of additional properties of these proteins has led to understanding of their roles as exquisite sensors that link metabolic activity to oxidative states. SIRTs have major roles in biological processes that are important in kidney development and physiological functions, including mitochondrial metabolism, oxidative stress, autophagy, DNA repair and inflammation. Furthermore, altered SIRT activity has been implicated in the pathophysiology and progression of acute and chronic kidney diseases, including acute kidney injury, diabetic kidney disease, chronic kidney disease, polycystic kidney disease, autoimmune diseases and renal ageing. The renoprotective roles of SIRTs in these diseases make them attractive therapeutic targets. A number of SIRT-activating compounds have shown beneficial effects in kidney disease models; however, further research is needed to identify novel SIRT-targeting strategies with the potential to treat and/or prevent the progression of kidney diseases and increase the average human healthspan.
(© 2024. Springer Nature Limited.)
Databáze: MEDLINE
Externí odkaz: