Self-Assembly of Rod-Coil Bottlebrush Copolymers into Degradable Nanodiscs with a UV-Triggered Self-Immolation Process.

Autor: Zeng H; Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, 2006, Sydney, NSW, Australia., Liang X; Department of Chemistry and Department of Chemical and Biochemical Engineering, The University of Western Ontario, N6A 5B7, London, Ontario, Canada., Roberts DA; Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, 2006, Sydney, NSW, Australia., Gillies ER; Department of Chemistry and Department of Chemical and Biochemical Engineering, The University of Western Ontario, N6A 5B7, London, Ontario, Canada., Müllner M; Key Centre for Polymers and Colloids, School of Chemistry, The University of Sydney, 2006, Sydney, NSW, Australia.; The University of Sydney Nano Institute (Sydney Nano), The University of Sydney, 2006, Sydney, NSW, Australia.
Jazyk: angličtina
Zdroj: Angewandte Chemie (International ed. in English) [Angew Chem Int Ed Engl] 2024 Mar 22; Vol. 63 (13), pp. e202318881. Date of Electronic Publication: 2024 Feb 22.
DOI: 10.1002/anie.202318881
Abstrakt: Polymer nanodiscs, especially with stimuli-responsive features, represent an unexplored frontier in the nanomaterial landscape. Such 2D nanomaterials are considered highly promising for advanced biomedicine applications. Herein, we designed a rod-coil copolymer architecture based on an amphiphilic, tadpole-like bottlebrush copolymer, which can directly self-assemble into core-shell nanodiscs in an aqueous environment. As the bottlebrush side chains are made of amorphous, UV-responsive poly(ethyl glyoxylate) (PEtG) chains, they can undergo rapid end-to-end self-immolation upon light irradiation. This triggered nanodisc disassembly can be used to boost small molecule release from the nanodisc core, which is further aided by a morphological change from discs to spheres.
(© 2024 The Authors. Angewandte Chemie International Edition published by Wiley-VCH GmbH.)
Databáze: MEDLINE
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