Deciphering the functional landscape and therapeutic implications of noncoding RNAs in the TGF-β signaling pathway in colorectal cancer: A comprehensive review.

Autor: Saadh MJ; Faculty of Pharmacy, Middle East University, Amman 11831, Jordan., Allela OQB; Department of Pharmacy, Al-Noor University College, Nineveh, Iraq. Electronic address: omerallela@alnoor.edu.iq., Sattay ZJ; Department of Medical Laboratory Technology l, University of imam Jaafar Al-Sadiq, Iraq., Al Zuhairi RAH; National University of Science and Technology, Dhi Qar, Iraq., Ahmad H; Section of Mathematics, International Telematic University Uninettuno, Corso Vittorio Emanuele II, 39, Rome 00186, Italy; Center for Applied Mathematics and Bioinformatics, Gulf University for Science and Technology, Kuwait; Department of Computer Science and Mathematics, Lebanese American University, Beirut, Lebanon., Eldesoky GE; Chemistry Department, College of Science, King Saud University, Riyadh 11451, Saudi Arabia., Adil M; Pharmacy college, Al-Farahidi University, Iraq., Ali MS; Department of Dentistry, Al-Zahrawi University College, Karbala, Iraq.
Jazyk: angličtina
Zdroj: Pathology, research and practice [Pathol Res Pract] 2024 Mar; Vol. 255, pp. 155158. Date of Electronic Publication: 2024 Jan 22.
DOI: 10.1016/j.prp.2024.155158
Abstrakt: Colorectal cancer (CRC) remains a major global health concern, necessitating an in-depth exploration of the intricate molecular mechanisms underlying its progression and potential therapeutic interventions. Transforming Growth Factor-β (TGF-β) signaling, a pivotal pathway implicated in CRC plays a dual role as a tumor suppressor in the early stages and a promoter of tumor progression in later stages. Recent research has shed light on the critical involvement of noncoding RNAs (ncRNAs) in modulating the TGF-β signaling pathway, introducing a new layer of complexity to our understanding of CRC pathogenesis. This comprehensive review synthesizes the current state of knowledge regarding the function and therapeutic potential of various classes of ncRNAs, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs), in the context of TGF-β signaling in CRC. The intricate interplay between these ncRNAs and key components of the TGF-β pathway is dissected, revealing regulatory networks that contribute to the dynamic balance between tumor suppression and promotion. Emphasis is placed on how dysregulation of specific ncRNAs can disrupt this delicate equilibrium, fostering CRC initiation, progression, and metastasis. Moreover, the review provides a critical appraisal of the emerging therapeutic strategies targeting ncRNAs associated with TGF-β signaling in CRC. The potential of these ncRNAs as diagnostic and prognostic biomarkers is discussed, highlighting their clinical relevance. Additionally, the challenges and prospects of developing RNA-based therapeutics, such as RNA interference and CRISPR/Cas-based approaches, are explored in the context of modulating TGF-β signaling for CRC treatment. In conclusion, this review offers a comprehensive overview of the intricate interplay between ncRNAs and the TGF-β signaling pathway in CRC. By unraveling the functional significance of these regulatory elements, we gain valuable insights into the molecular landscape of CRC, paving the way for the development of novel and targeted therapeutic interventions aimed at modulating the TGF-β signaling cascade through the manipulation of ncRNAs.
Competing Interests: Declaration of Competing Interest None.
(Copyright © 2024 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: