Intention-to-Treat Analysis in Clinical Research: Basic Concepts for Clinicians.

Autor:	Armijo-Olivo S; From the University of Applied Sciences Osnabrück, Faculty of Economics and Social Sciences, Osnabrück, Germany (SA-O, AISDO-S, NB); Faculties of Rehabilitation Medicine and Medicine and Dentistry, University of Alberta, Edmonton, Canada (SA-O) Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada; Post Graduate Program in Physical Therapy, Federal University of São Carlos-UFSCar, São Carlos, Brazil (JB-S); Post Graduate Program in Human Movement Sciences, Methodist University of Piracicaba-UNIMEP, Piracicaba, Brazil (EMDC-C); Post-Graduation Program in Oral and Maxillofacial Surgery, Piracicaba Dental School, State University of Campinas-UNICAMP, Piracicaba (SP), Brazil (EBP); Faculty of Rehabilitation Medicine, University of Alberta, Edmonton, Canada (NM, FB, LD); Faculty of Health Science, Center of Physiotherapy, Universiti Teknologi MARA, Puncak Alam, Malaysia (NM); Institute of Health Policy, Management and Evaluation, University of Toronto, Toronto, Canada (JPS); Toronto Rehabilitation Institute, University Health Network, Toronto, Canada (JPS); and Division of Physical Medicine and Rehabilitation, Department of Medicine, University of Toronto, Toronto, Canada (DK)., Barbosa-Silva J, de Castro-Carletti EM, de Oliveira-Souza AIS, Pelai EB, Mohamad N, Baghbaninaghadehi F, Dennett L, Steen JP, Kumbhare D, Ballenberger N
Jazyk:	angličtina
Zdroj:	American journal of physical medicine & rehabilitation [Am J Phys Med Rehabil] 2024 Sep 01; Vol. 103 (9), pp. 845-857. Date of Electronic Publication: 2024 Feb 06.
DOI:	10.1097/PHM.0000000000002444
Abstrakt:	Abstract: This review presents a comprehensive summary and critical evaluation of intention-to-treat analysis, with a particular focus on its application to randomized controlled trials within the field of rehabilitation. Adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, we conducted a methodological review that encompassed electronic and manual search strategies to identify relevant studies. Our selection process involved two independent reviewers who initially screened titles and abstracts and subsequently performed full-text screening based on established eligibility criteria. In addition, we included studies from manual searches that were already cataloged within the first author's personal database. The findings are synthesized through a narrative approach, covering fundamental aspects of intention to treat, including its definition, common misconceptions, advantages, disadvantages, and key recommendations. Notably, the health literature offers a variety of definitions for intention to treat, which can lead to misinterpretations and inappropriate application when analyzing randomized controlled trial results, potentially resulting in misleading findings with significant implications for healthcare decision making. Authors should clearly report the specific intention-to-treat definition used in their analysis, provide details on participant dropouts, and explain upon their approach to managing missing data. Adherence to reporting guidelines, such as the Consolidated Standards of Reporting Trials for randomized controlled trials, is essential to standardize intention-to-treat information, ensuring the delivery of accurate and informative results for healthcare decision making. Competing Interests: Financial disclosure statements have been obtained, and no conflicts of interest have been reported by the authors or by any individuals in control of the content of this article. (Copyright © 2024 Wolters Kluwer Health, Inc. All rights reserved.)
Databáze:	MEDLINE
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