Cross Dehydrogenative Coupling of SF 4 -Alkyne with Tetrahydroisoquinolines.

Autor: Yadav AK; Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-Ku, Nagoya 466-8555, Japan.; Baba Raghav Das Post Graduate College, Deoria, Uttar Pradesh 274001, India., Ariff PNAM; Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-Ku, Nagoya 466-8555, Japan., Kawai K; Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-Ku, Nagoya 466-8555, Japan., Ochiai S; Department of Engineering, Nagoya Institute of Technology, Gokiso, Showa-Ku, Nagoya 466-8555, Japan., Narra SR; Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-Ku, Nagoya 466-8555, Japan., Shibata N; Department of Nanopharmaceutical Sciences, Nagoya Institute of Technology, Gokiso, Showa-Ku, Nagoya 466-8555, Japan.; Department of Engineering, Nagoya Institute of Technology, Gokiso, Showa-Ku, Nagoya 466-8555, Japan.
Jazyk: angličtina
Zdroj: Organic letters [Org Lett] 2024 Feb 23; Vol. 26 (7), pp. 1442-1446. Date of Electronic Publication: 2024 Feb 06.
DOI: 10.1021/acs.orglett.4c00080
Abstrakt: This study introduces a dual-catalytic method for cross-dehydrogenative coupling (CDC) between tetrahydroisoquinolines and Py-SF 4 -alkyne using visible-light photoredox catalysis. This protocol enables selective C(sp 3 )-H alkynylation, expanding the synthetic toolkit for SF 4 -based molecules. Demonstrating efficiency and substrate versatility, this approach opens new avenues in hexacoordinated tetrafluorinated sulfur chemistry and CDC strategies and holds significant promise for drug discovery and materials science.
Databáze: MEDLINE
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