A Review of Hypoxia Imaging Using 18F-Fluoromisonidazole Positron Emission Tomography.

Autor: Hirata K; Department of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Japan. khirata@med.hokudai.ac.jp.; Department of Nuclear Medicine, Hokkaido University Hospital, Sapporo, Japan. khirata@med.hokudai.ac.jp.; Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan. khirata@med.hokudai.ac.jp., Watanabe S; Department of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.; Department of Nuclear Medicine, Hokkaido University Hospital, Sapporo, Japan.; Global Center for Biomedical Science and Engineering, Faculty of Medicine, Hokkaido University, Sapporo, Japan., Kitagawa Y; Oral Diagnosis and Medicine, Department of Oral Pathobiological Science, Graduate School of Dental Medicine, Hokkaido University, Sapporo, Hokkaido, Japan., Kudo K; Department of Diagnostic Imaging, Graduate School of Medicine, Hokkaido University, Sapporo, Japan.; Department of Nuclear Medicine, Hokkaido University Hospital, Sapporo, Japan.; Department of Diagnostic and Interventional Radiology, Hokkaido University Hospital, Sapporo, Japan.
Jazyk: angličtina
Zdroj: Methods in molecular biology (Clifton, N.J.) [Methods Mol Biol] 2024; Vol. 2755, pp. 133-140.
DOI: 10.1007/978-1-0716-3633-6_9
Abstrakt: Tumor hypoxia is an essential factor related to malignancy, prognosis, and resistance to treatment. Positron emission tomography (PET) is a modality that visualizes the distribution of radiopharmaceuticals administered into the body. PET imaging with [ 18 F]fluoromisonidazole ([ 18 F]FMISO) identifies hypoxic tissues. Unlike [ 18 F]fluorodeoxyglucose ([ 18 F]FDG)-PET, fasting is not necessary for [ 18 F]FMISO-PET, but the waiting time from injection to image acquisition needs to be relatively long (e.g., 2-4 h). [ 18 F]FMISO-PET images can be displayed on an ordinary commercial viewer on a personal computer (PC). While visual assessment is fundamental, various quantitative indices such as tumor-to-muscle ratio have also been proposed. Several novel hypoxia tracers have been invented to compensate for the limitations of [ 18 F]FMISO.
(© 2024. The Author(s), under exclusive license to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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