Synaptic cell-adhesion molecule latrophilin-2 is differentially directed to dendritic domains of hippocampal neurons.

Autor:	Murphy TR; Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, CA 92521, USA., Amidon RF; Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, CA 92521, USA.; School of Medicine, Medical College of Wisconsin, Milwaukee, WI 53226, USA., Donohue JD; Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, CA 92521, USA.; Neuroscience Graduate Program, University of California, Riverside, Riverside, CA 92521, USA., Li L; Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, CA 92521, USA., Anderson GR; Department of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, CA 92521, USA.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Jan 16; Vol. 27 (2), pp. 108799. Date of Electronic Publication: 2024 Jan 16 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.108799
Abstrakt:	Hippocampal pyramidal cells possess elaborate dendritic arbors with distinct domains that are targeted with input-specific synaptic sites. This synaptic arrangement is facilitated by synaptic cell-adhesion molecules that act as recognition elements to connect presynaptic and postsynaptic neurons. In this study, we investigate the organization of the synaptic recognition molecule latrophilin-2 at the surface of pyramidal neurons classified by spatial positioning and action potential firing patterns. Surveying two hippocampal neurons that highly express latrophilin-2, late-bursting CA1 pyramidal cells and early-bursting subiculum pyramidal cells, we found the molecule to be differentially positioned on their respective dendritic compartments. Investigating this latrophilin-2 positioning at the synaptic level, we found that the molecule is not present within either the pre- or postsynaptic terminal but rather is tightly coupled to synapses at a perisynaptic location. Together these findings indicate that hippocampal latrophilin-2 distribution patterning is cell-type specific, and requires multiple postsynaptic neurons for its synaptic localization. Competing Interests: The authors declare no competing interests. (© 2024 The Author(s).)
Databáze:	MEDLINE
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