Defining the "Correlate(s) of Protection" to tick-borne encephalitis vaccination and infection - key points and outstanding questions.

Autor: Ackermann-Gäumann R; Microbiologie, ADMED Analyses et Diagnostics Médicaux, La Chaux-de-Fonds, Switzerland.; Swiss National Reference Center for Tick-transmitted Diseases, La Chaux-de-Fonds, Switzerland., Lang P; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland., Zens KD; Epidemiology, Biostatistics and Prevention Institute, University of Zurich, Zurich, Switzerland.; Institute for Experimental Immunology, University of Zurich, Zurich, Switzerland.
Jazyk: angličtina
Zdroj: Frontiers in immunology [Front Immunol] 2024 Jan 22; Vol. 15, pp. 1352720. Date of Electronic Publication: 2024 Jan 22 (Print Publication: 2024).
DOI: 10.3389/fimmu.2024.1352720
Abstrakt: Tick-borne Encephalitis (TBE) is a severe disease of the Central Nervous System (CNS) caused by the tick-borne encephalitis virus (TBEV). The generation of protective immunity after TBEV infection or TBE vaccination relies on the integrated responses of many distinct cell types at distinct physical locations. While long-lasting memory immune responses, in particular, form the basis for the correlates of protection against many diseases, these correlates of protection have not yet been clearly defined for TBE. This review addresses the immune control of TBEV infection and responses to TBE vaccination. Potential correlates of protection and the durability of protection against disease are discussed, along with outstanding questions in the field and possible areas for future research.
Competing Interests: PL reports honoraria for lectures and/or research grants from Pfizer. RA-G and KZ report honoraria for lectures and/or research grants from Pfizer and Bavarian Nordic. This work was supported by a grant from Pfizer awarded to RA-G and KZ. The funder had the following involvement in the study: conceptualization of the study and review of the manuscript.
(Copyright © 2024 Ackermann-Gäumann, Lang and Zens.)
Databáze: MEDLINE