Comparing Hearing Loss in Children with Adults Living with Sickle Cell Disease and Sickle Cell Traits.

Autor:	Ibekwe TS; Department of Otorhinolaryngology, University of Abuja, South Africa.; Division of Communication Sciences and Disorders, Department of Health and Rehabilitation Sciences, University of Cape Town, South Africa., Rogers C; Division of Communication Sciences and Disorders, Department of Health and Rehabilitation Sciences, University of Cape Town, South Africa., Ramma L; Division of Communication Sciences and Disorders, Department of Health and Rehabilitation Sciences, University of Cape Town, South Africa.
Jazyk:	angličtina
Zdroj:	Nigerian journal of clinical practice [Niger J Clin Pract] 2024 Jan 01; Vol. 27 (1), pp. 74-81. Date of Electronic Publication: 2024 Feb 05.
DOI:	10.4103/njcp.njcp_763_23
Abstrakt:	Background: Hearing loss is a neurological sequelae associated with sickle cell disease (SCD) and probably sickle cell trait (SCT) in children and adults but remains understudied. Aim: This study aimed to compare the hearing impairment among children and adults living with SCD or SCT. Methods: A comparative cross-sectional study conducted in four departments with SCD outpatient clinic in a tertiary hospital in Nigeria. Participants with Sickle cell disease (HbSS) and Sickle cell trait (HbAS) (cohort) and HbAA (control) had comprehensive ear and hearing assessments for sensorineural hearing loss. Audiometric results were categorized according to WHO classifications and data analysed with Statistical Analysis System (SAS 9.4). Results: A total of 212 participants (106 cohort and control, respectively), aged 6 months to 55 years, were enrolled. Of these, 35% of children with SCD and 25% with SCT had hearing impairment, while 30% of adults with SCD, 36.1% with SCT, and 11% with HbAA had hearing impairment. There was asymmetry in the hearing impairment, with the left ear more affected in children and the right ear in adults. The odds ratio (OD) of hearing impairment was higher in HbSS (2.48 (95% confidence interval (CI):1.51-4.14); P = 0.0004) and HbAS (2.28 (95% CI: 1.1-4.58); P = 0.02) participants compared with HbAA but was not statistically significant when adjusted for frequency of hospitalization, crises, blood transfusion and routine drugs in HbAS (P = 0.49) unlike HbSS (P = 0.03). Conclusion: The prevalence of hearing loss among children and adults with SCD is higher than in those with HbA genotype. The frequency of hospitalization, crises, blood transfusion and taking routine drugs may influence hearing impairment in SCT but may not in SCD. (Copyright © 2024 Copyright: © 2024 Nigerian Journal of Clinical Practice.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu