Extracellular vesicles in parasitic diseases - from pathogenesis to future diagnostic tools.

Autor: Menezes SA; Faculdade de Farmácia e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil. Electronic address: saulomenezes99@gmail.com., Tasca T; Faculdade de Farmácia e Centro de Biotecnologia, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil. Electronic address: tiana.tasca@ufrgs.br.
Jazyk: angličtina
Zdroj: Microbes and infection [Microbes Infect] 2024 May-Jun; Vol. 26 (4), pp. 105310. Date of Electronic Publication: 2024 Feb 04.
DOI: 10.1016/j.micinf.2024.105310
Abstrakt: Parasitic diseases are still a major public health problem especially among individuals of low socioeconomic status in underdeveloped countries. In recent years it has been demonstrated that parasites can release extracellular vesicles that participate in the host-parasite communication, immune evasion, and in governing processes associated with host infection. Extracellular vesicles are membrane-bound structures released into the extracellular space that can carry several types of biomolecules, including proteins, lipids, nucleic acids, and metabolites, which directly impact the target cells. Extracellular vesicles have attracted wide attention due to their relevance in host-parasite communication and for their potential value in applications such as in the diagnostic biomarker discovery. This review of the literature aimed to join the current knowledge on the role of extracellular vesicles in host-parasite interaction and summarize its molecular content, providing information for the acquisition of new tools that can be used in the diagnosis of parasitic diseases. These findings shed light to the potential of extracellular vesicle cargo derived from protozoan parasites as novel diagnostic tools.
Competing Interests: Declaration of competing interest The authors declare no conflict of interest.
(Copyright © 2024 Institut Pasteur. Published by Elsevier Masson SAS. All rights reserved.)
Databáze: MEDLINE
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