Polydioxanone Bioactive Sutures-Acetyl Hexapeptide-8 (Argireline): An Intelligent System for Controlled Release in Facial Harmonization.
| Autor: | Velazco de Maldonado GJ; Department of Restorative Dentistry, Dental Research Center, University of Los Andes (ULA), Mérida, Venezuela., Suárez-Vega DV; Department of Investigation, Dental Research Center, University of Los Andes, (ULA), Mérida, Venezuela., Miller-Kobisher B; Academic Division, Pan-American Institute of Scientific Professionals (IPPC), Mexico City, Mexico., García-Guevara VJ; Academic and Research Division, Aesthetic Medicine Studies Center Foundation (FUCEME), Caracas, Venezuela. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of cutaneous and aesthetic surgery [J Cutan Aesthet Surg] 2023 Oct-Dec; Vol. 16 (4), pp. 325-334. |
| DOI: | 10.4103/JCAS.JCAS_34_23 |
| Abstrakt: | Introduction: We propose a new facial lifting protocol using polydioxanone (PDO) threads embedded in acetyl hexapeptide-8 (Argireline [Arg]). We assume that Arg reinforces the effects of PDO threads, as it is a mimetic of botulinum toxin. Because the PDO suture is hydrolyzable, this assumption is analyzed by instrumental analysis. Objective: To demonstrate the capacity of the PDO suture as a system for the controlled release of acetyl hexapeptide-8 to apply in deep wrinkles of the upper third. Materials and Methods: Three segments of 1-cm long 21G PDO threads immersed in 1 mL of Arg. PDO threads were observed under an optical, electron microscope at 24, 48, and 72 h later. They were also weighed before and after being soaked in Arg, and employing ultraviolet (UV)-visible spectroscopy, the release rate of Arg from the PDO suture was measured. Finally, was insert the thread PDO-Arg following a protocol designed especially for deep static wrinkles in the upper third. Results: The electronic weighing revealed that the PDO thread enjoys capillarity by the peptide, doubling its weight every 24 h. UV spectra revealed that PDO thread is a well-controlled release system for Arg, allowing its sustained release for 1 h. Optical and electronic photomicrographs confirm the swelling of the PDO thread by absorbing Arg by its capillarity, but this hydrophilicity does not lead to its premature physical degradation. Conclusions: The PDO thread system with Arg is an intelligent bioactive system useful in facial harmonization. It recommend conduct clinical trial to verify his superior lifting effect. Competing Interests: There are no conflicts of interest. (Copyright: © 2023 Journal of Cutaneous and Aesthetic Surgery.) |
| Databáze: | MEDLINE |
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