Blood and Imaging Biomarkers in the Long-term Follow-up of Bicuspid Aortic Valve Patients.

Autor:	Keuning ZA; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Hendriks PM; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Duijnhouwer AL; Department of Cardiology, Radboud University Medical Centre, Nijmegen, The Netherlands., Meccanici F; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Siebelink HJ; Department of Cardiology, Leiden University Medical Centre, Leiden, The Netherlands., van den Hoven AT; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Geenen LW; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Eindhoven JA; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Baggen VJM; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Cuypers JAAE; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Kauling RM; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands., Roos-Hesselink JW; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.; ERN-GUARD-Heart: European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Amsterdam, The Netherlands., van den Bosch AE; Department of Cardiology, Erasmus MC, University Medical Centre Rotterdam, Rotterdam, The Netherlands.; ERN-GUARD-Heart: European Reference Network for Rare and Low Prevalence Complex Diseases of the Heart, Amsterdam, The Netherlands.
Jazyk:	angličtina
Zdroj:	CJC open [CJC Open] 2023 Sep 23; Vol. 6 (1), pp. 1-10. Date of Electronic Publication: 2023 Sep 23 (Print Publication: 2024).
DOI:	10.1016/j.cjco.2023.09.012
Abstrakt:	Background: Bicuspid aortic valve (BAV) is a common congenital heart defect. Patients with BAV are at risk for long-term complications such as valve stenosis and regurgitation. This study aimed to investigate sex differences in blood and imaging biomarkers and to describe the long-term prognostic value of blood and echocardiographic biomarkers. Methods: Patients were included from 2 prospective observational cohort studies; they underwent venous blood sampling and transthoracic echocardiography including speckle tracking. Analyzed blood biomarkers were red-cell distribution width (RDW), creatinine, C-reactive protein (CRP), troponin T, N-terminal pro B-type natriuretic peptide (NT-proBNP), and transforming growth factor-beta (TGF-β). Sex differences were analyzed at baseline. Associations between biomarkers and arrhythmia-free and intervention-free survival were determined by Cox regression, adjusted for age and sex. Results: A total of 182 patients with BAV were included: median age 34; interquartile range [IQR]: 23-46 years; 55.5% male. CRP, NT-proBNP, and RDW were higher in women, whereas creatinine, troponin T and TGF-β were higher among men. After a median follow-up time of 6.9 (IQR: 6.5-9.9) years, arrhythmia-free and intervention-free survival was, 81.0% and 73.1%, respectively. NT-proBNP was associated with both arrhythmia-free and intervention-free survival (hazard ratio [HR], 1.94, P  = 0.005 and HR, 2.06, P  = 0.002, respectively). On echocardiography higher left atrial (LA) size, left ventricular end-diastolic diameter (LVEDD), left ventricular (LV) mass index and E/e' ratio were associated with lower arrhythmia-free survival, whereas higher LA size, LV mass index, aortic valve peak velocity, and aortic regurgitation were associated with lower intervention-free survival. Conclusions: Differences were observed in blood biomarkers between men and women with BAV. Besides LV systolic parameters, diastolic LV function and NT-proBNP should have a more prominent role as prognostic markers in clinical care. (© 2023 The Authors.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu