Differential mucosal tropism and dissemination of classical and hypervirulent Klebsiella pneumoniae infection.

Autor:	Teo TH; Agency for Science, Technology and Research (A∗STAR), Infectious Diseases (ID) Labs, Singapore 429621, Singapore., Ayuni NN; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore., Yin M; Agency for Science, Technology and Research (A∗STAR), Infectious Diseases (ID) Labs, Singapore 429621, Singapore., Liew JH; Agency for Science, Technology and Research (A∗STAR), Infectious Diseases (ID) Labs, Singapore 429621, Singapore.; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore., Chen JQ; Agency for Science, Technology and Research (A∗STAR), Infectious Diseases (ID) Labs, Singapore 429621, Singapore., Kurepina N; Hackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ 07110, USA., Rajarethinam R; Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A∗STAR), Singapore 138673, Singapore., Kreiswirth BN; Hackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ 07110, USA., Chen L; Hackensack Meridian Health Center for Discovery and Innovation, Nutley, NJ 07110, USA., Bifani P; Agency for Science, Technology and Research (A∗STAR), Infectious Diseases (ID) Labs, Singapore 429621, Singapore.; Infectious Diseases Translational Research Programme, Department of Microbiology and Immunology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117545, Singapore.; Department of Infection Biology, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London WC1E7HT, UK.
Jazyk:	angličtina
Zdroj:	IScience [iScience] 2024 Jan 11; Vol. 27 (2), pp. 108875. Date of Electronic Publication: 2024 Jan 11 (Print Publication: 2024).
DOI:	10.1016/j.isci.2024.108875
Abstrakt:	Klebsiella pneumoniae (Kp) infection is an important healthcare concern. The ST258 classical (c)Kp strain is dominant in hospital-acquired infections in North America and Europe, while ST23 hypervirulent (hv)Kp prevails in community-acquired infections in Asia. This study aimed to develop symptomatic mucosal infection models in mice that mirror natural infections in humans to gain a deeper understanding of Kp mucosal pathogenesis. We showed that cKp replicates in the nasal cavity instead of the lungs, and this early infection event is crucial for the establishment of chronic colonization in the cecum and colon. In contrast, hvKp replicates directly in the lungs to lethal bacterial load, and early infection of esophagus supported downstream transient colonization in the ileum and cecum. Here, we have developed an in vivo model that illuminates how differences in Kp tropism are responsible for virulence and disease phenotype in cKp and hvKp, providing the basis for further mechanistic study. Competing Interests: All authors declare no conflicts of interest. (© 2024 The Authors.)
Databáze:	MEDLINE
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