Insulin signaling and pharmacology in humans and in corals.

Autor:	Murthy MHS; School of Molecular Sciences, Arizona State University, Phoenix, AZ, USA., Jasbi P; School of Molecular Sciences, Arizona State University, Phoenix, AZ, USA., Lowe W; Departments of Chemistry & Physics, Colorado School of Mines, Golden, CO, United States., Kumar L; Departments of Chemistry & Physics, Colorado School of Mines, Golden, CO, United States., Olaosebikan M; Department of Computer Science, Tufts University, Medford, MA, USA., Roger L; School of Molecular Sciences, Arizona State University, Phoenix, AZ, USA.; School of Ocean Futures, Arizona State University, Tempe, AZ, United States of America., Yang J; Department of Aeronautics & Astronautics, University of Washington, Seattle, WA, USA., Lewinski N; Department of Chemical and Life Science Engineering, Virginia Commonwealth University, Richmond, VA, USA., Daniels N; Department of Computer Science, University of Rhode Island, Kingston, RI, USA., Cowen L; Department of Computer Science, Tufts University, Medford, MA, USA., Klein-Seetharaman J; School of Molecular Sciences, Arizona State University, Phoenix, AZ, USA.; Departments of Chemistry & Physics, Colorado School of Mines, Golden, CO, United States.; College of Health Solutions, Arizona State University, Phoenix, AZ, United States.
Jazyk:	angličtina
Zdroj:	PeerJ [PeerJ] 2024 Jan 31; Vol. 12, pp. e16804. Date of Electronic Publication: 2024 Jan 31 (Print Publication: 2024).
DOI:	10.7717/peerj.16804
Abstrakt:	Once thought to be a unique capability of the Langerhans islets in the pancreas of mammals, insulin (INS) signaling is now recognized as an evolutionarily ancient function going back to prokaryotes. INS is ubiquitously present not only in humans but also in unicellular eukaryotes, fungi, worms, and Drosophila . Remote homologue identification also supports the presence of INS and INS receptor in corals where the availability of glucose is largely dependent on the photosynthetic activity of the symbiotic algae. The cnidarian animal host of corals operates together with a 20,000-sized microbiome, in direct analogy to the human gut microbiome. In humans, aberrant INS signaling is the hallmark of metabolic disease, and is thought to play a major role in aging, and age-related diseases, such as Alzheimer's disease. We here would like to argue that a broader view of INS beyond its human homeostasis function may help us understand other organisms, and in turn, studying those non-model organisms may enable a novel view of the human INS signaling system. To this end, we here review INS signaling from a new angle, by drawing analogies between humans and corals at the molecular level. Competing Interests: The authors declare that they have no competing interests. (© 2024 Murthy et al.)
Databáze:	MEDLINE
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