Instant and short-term effects of acupuncture for depression and anxiety in unstable angina pectoris patients with percutaneous coronary interventions.
| Autor: | Pei JH; Department of Cardiovascular Medicine, Beijing Aerospace General Hospital, Beijing, China., Gan F; Department of Cardiovascular Medicine, Beijing Aerospace General Hospital, Beijing, China., Bai YH; Department of Cardiovascular Medicine, Beijing Aerospace General Hospital, Beijing, China., Xing YL; Department of Cardiovascular Medicine, Beijing Aerospace General Hospital, Beijing, China., Jia JJ; Institute of Geriatrics, Chinese People's Liberation Army General Hospital, Beijing, China., Wang H; The Second Medical Center, Chinese PLA General Hospital, Beijing, China. |
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| Jazyk: | angličtina |
| Zdroj: | Frontiers in cardiovascular medicine [Front Cardiovasc Med] 2024 Jan 19; Vol. 11, pp. 1173080. Date of Electronic Publication: 2024 Jan 19 (Print Publication: 2024). |
| DOI: | 10.3389/fcvm.2024.1173080 |
| Abstrakt: | Aim: Patients with unstable angina pectoris (UAP) usually present anxiety or depression during percutaneous coronary intervention (PCI). This study sought to investigate the instant and short-term effects of acupuncture for anxiety and depression in UAP patients with PCI. Methods: A total of 210 UAP patients who underwent PCI were recruited and randomly assigned (1:1:1) to acupuncture, placebo, or control groups. Enzyme-linked immunosorbent assay was used to detect the levels of fasting glucose, fasting insulin, homeostasis model assessment of insulin resistance (HOMA-IR), interleukin-6 (IL-6), high-sensitivity C-reactive protein (Hs-CRP), advanced oxidation protein products (AoPPs), and oxidized low-density lipoprotein (OX-LDL). Serial questionnaires with the Hamilton Anxiety (HAMA) scale and the Pittsburgh Sleep Quality Index were evaluated, and heart rate variability indicators were obtained. Results: Primary end-point: low frequency/high frequency (HF) was lower in the electroacupuncture group ( p = 0.014), while standard deviation of normal-to-normal intervals, average standard deviation of normal-to-normal intervals, percentage of successive intervals that differ more than 50 ms, and HF were increased with acupuncture ( p = 0.018, p = 0.043, p = 0.016, and p = 0.002, respectively). Secondary end-point: significant improvements in anxiety levels (HAMA) were observed in the three groups ( p < 0.001). The fasting insulin and HOMA-IR levels were similar between the control group and the acupuncture group ( p = 0.285 and p = 0.165, respectively). The levels of IL-6 and AoPPs differed among the three groups ( p = 0.021 and p < 0.001, respectively). However, no significant differences were found in fasting plasma glucose, fasting c-peptide, Hs-CRP, and OX-LDL levels among the three groups ( p = 0.585, p = 0.611, p = 0.902, and p = 0.756, respectively). Conclusions: In this study, short-term acupuncture may potentially relieve clinical symptoms before PCI treatment. Clinical Trial Registration: ClinicalTrials.gov, identifier (NCT03789344). Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. (© 2024 Pei, Gan, Bai, Xing, Jia and Wang.) |
| Databáze: | MEDLINE |
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