| Autor: |
Shutova AS; Endocrinology Research Centre., Pigarova EA; Endocrinology Research Centre., Lepeshkina LI; Peoples' Friendship University of Russia named after Patrice Lumumba., Ioutsi VA; Endocrinology Research Centre., Drokov MY; National medical Research Center for Hematology., Vorotnikova SY; Endocrinology Research Centre., Astafyeva LI; Burdenko Neurosurgical Institute., Dzeranova LK; National medical Research Center for Hematology. |
| Jazyk: |
ruština |
| Zdroj: |
Problemy endokrinologii [Probl Endokrinol (Mosk)] 2024 Jan 24; Vol. 69 (6), pp. 63-69. Date of Electronic Publication: 2024 Jan 24. |
| DOI: |
10.14341/probl13351 |
| Abstrakt: |
The main treatment option of prolactin-secreting pituitary adenomas is dopamine agonist therapy, which demonstrates prolactin level normalizing and reducing the size of an adenoma in the majority of cases. However, significant amount of patients - about 20% - poorly responds even to high doses of dopamine agonists that is explained by the resistance to therapy. The occurrence of pharmacodynamic characteristics is one of the causes responsible for the development of resistance to typical therapy. Clinical manifestations of persistent hyperprolactinemia are due to following pathological factors: hormonal hypersecretion and the mass-effect of pituitary adenoma. Prevention of irreversible changes is possible only with timely detection of resistance and determination of the optimal personalized treatment algorithm.We report a clinical case of dopamine-agonist resistant microprolactinoma. Patient's health stabilisation, normal level of prolactin and reduction in size of adenoma were achieved due to administration of combined treatment with tamoxifen and dopamine agonists. Hyperprolactinaemia occurring because of prolactin-secreting pituitary adenoma and associated adverse effects are significant problem, decreasing quality of life and demographics in general. This underlines the importance of figuring out causes and identifying predictors of the therapy resistance.The results of the study, illustrated by a clinical example, are presented in the present paper. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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